| 应激性溃疡的发生及川芎嗪的防治效应 |
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| 引用本文： | 董淑云,郑素琴,门秀丽,张硕森,景肖伶,张连元.应激性溃疡的发生及川芎嗪的防治效应[J].中国中西医结合消化杂志,1996(4). |
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| 作者姓名： | 董淑云 郑素琴 门秀丽 张硕森 景肖伶 张连元 |
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| 作者单位： | 华北煤炭医学院病理生理学教研室!唐山063000 |
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| 基金项目： | 煤炭工业部科研基金资助课题 |
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| 摘 要： | 本实验观察了家兔创伤后胃粘膜损伤情况及川芎嗪的防治效应。发现动物创伤后目粘膜损伤严重．出现应激性溃疡．同时血浆和胃粘膜组织中脂质过氧化物商二醇含量增加，且胃粘膜细胞有明显的钙积聚。而应用川芎嗪防治的动物．脂质过氧化反应被明显地抑制，钙超载现象显著减轻．胃粘膜损伤轻微。提示，应激性溃疡的发生与自由基反应和细胞内钙超载有关，川芎嗪对应激性溃疡具有防治作用。
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| 关 键 词： | 川芎嗪 应激性溃疡 创伤 丙二醛 钙超载 |
Effeet of ligustrazine on the stress ulcer |
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| Dong Shuyun, Zheng Suqin, Men Xouli et al.Effeet of ligustrazine on the stress ulcer[J].Chinese Journal of Integrated Traditional and Western Medicine on Digestion,1996(4). |
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| Authors: | Dong Shuyun Zheng Suqin Men Xouli |
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| Abstract: | We observed the changes of gastric mucosal and effect of Ligustrazine on the traumatic rabbits. It was found that the stress ulcer occurred after trauma. In the plasma and gastric mucosal cells. the malondialdehyde (MDA ) content which is the metabolite of lipid peroxides increased, and on the same time, the calcium accumlated significantly in the gastric mucosal cells. However,treatment with Ligustrazine of traumatic rabbits could alleviate lipid peroxides reaction and calcium overload. The gastric mucosal lesion was very light. Results suggested that Ligustrazine may prevent stress ulcer. |
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| Keywords: | Ligustrazine Stress ulcer Trauma Malondialdehyde Calcium overload |
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