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Thymic epithelial tumor with superior vena cava syndrome diagnosed by percutaneous endovascular tumor biopsy: A report of two cases
Institution:1. First Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto, Japan;2. Department of Laboratory Medicine, Shinshu University School of Medicine, Matsumoto, Japan;3. Department of Comprehensive Cancer Therapy, Shinshu University School of Medicine, Matsumoto, Japan;1. Department of Respiratory Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishiku, Kitakyushu City, Fukuoka, 807-8555, Japan;2. Department of Microbiology, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishiku, Kitakyushu City, Fukuoka, 807-8555, Japan;3. Department of Respiratory Medicine, Unit of Translational Medicine, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki City, Nagasaki, 852-8501, Japan;1. Department of Respiratory Medicine and Allergology, Kindai University Faculty of Medicine, 377-2 Ohnohigashi, Osakasayama, Osaka, 589-8511, Japan;2. Kinki Hokuriku Airway Disease Conference, 377-2 Ohnohigashi, Osakasayama, Osaka, 589-8511, Japan;3. NPO Sapporo Cough Asthma and Allergy Center, Minami 4-jo Nishi 15-chome, Chuo-ku, Sapporo, 064-0804, Japan;4. Hiroshima Allergy and Respiratory Clinic, 14-7 Hatchobori, Naka-ku, Hiroshima, 730-0013, Japan;1. Department of Respiratory Medicine and Infectious Disease, Graduate School of Medicine, Yamaguchi University, 1-1-1 Minami-kogushi, Ube, 755-8505, Japan;2. Department of Medicine and Clinical Science, Graduate School of Medicine, Yamaguchi University, 1-1-1 Minami-kogushi, Ube, 755-8505, Japan;1. Department of Respiratory Medicine, Nara Medical University, 840 Shijo-cho, Kashihara-city, Nara, 634-8522, Japan;2. Department of Respiratory Medicine, Minami-Nara General Medical Center, 8-1 Fukugami, Oyodo-cho, Yoshino-gun, Nara, 638-8551, Japan;3. TME Therapeutics Inc., 2-16-1 Higashi-shinbashi, Minato-ku, Tokyo, 105-0021, Japan;4. Respiratory Disease Center, Fukujuji Hospital, Japan Anti-Tuberculosis Association, 3-1-24 Matsuyama, Kiyose-city, Tokyo, 204-8522, Japan;1. Kanagawa Cardiovascular and Respiratory Center, Department of Respiratory Medicine, Tomioka-Higashi 6-16-1, Kanazawa-ku, Yokohama, 236-0051, Japan;2. University of Yamanashi Hospital, Department of Internal Medicine 2, Shimokato 1110, Chuo-shi, Yamanashi, 409-3898, Japan
Abstract:Thymic epithelial tumor is a rare, potentially progressive disease that commonly infiltrates mediastinal structures. In rare cases, it may cause superior vena cava syndrome. Pretreatment histopathological diagnosis is essential to determine the most effective treatment strategy. Percutaneous endovascular biopsy is a rarely reported non-surgical diagnostic option for large vessel tumoral involvement. We report two cases of thymic epithelial tumor with superior vena cava syndrome diagnosed by percutaneous endovascular biopsy. No procedural complications occurred, and subsequent systemic treatment was promptly administered. This procedure may have potential as a useful diagnostic method for patients with mediastinal tumors involving large vessels.
Keywords:Thymic carcinoma  Superior vena cava syndrome  Percutaneous endovascular tumor biopsy  Mediastinal neoplasms  CT"}  {"#name":"keyword"  "$":{"id":"kwrd0035"}  "$$":[{"#name":"text"  "_":"Computed tomography  SVC"}  {"#name":"keyword"  "$":{"id":"kwrd0045"}  "$$":[{"#name":"text"  "_":"superior vena cava  SVCS"}  {"#name":"keyword"  "$":{"id":"kwrd0055"}  "$$":[{"#name":"text"  "_":"superior vena cava syndrome
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