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Cystathionine beta synthase deficiency promotes oxidative stress, fibrosis, and steatosis in mice liver

Authors:	Robert Karine Nehmé Johnny Bourdon Emmanuel Pivert Gérard Friguet Bertrand Delcayre Claude Delabar Jean-Maurice Janel Nathalie

Institution:	EA 3508, Université Paris 7-Denis Diderot, France.

Abstract:

Keywords:	α-SMA α-smooth muscle actin BHMT betaine-homocysteine methyltransferase CBS cystathionine β synthase CBS +/+ mice wild-type mice CBS +/? mice heterozygous CBS-deficient mice CBS ?/? mice homozygous CBS-deficient mice DNPH 2 4-dinitrophenylhydrazine GSH glutathione Hcy homocysteine HSCs hepatic stellate cells 4-HNE 4-hydroxyalkenal HO-1 heme oxygenase-1 IL-6 interleukin 6 MDA malondialdehyde MS methionine synthase MTHFR methylenetetrahydrofolate reductase ROS reactive oxygen species RPS3a ribosomal protein S3a SAM S-adenosylmethionine SAH S-adenosylhomocysteine SOD1 Cu Zn superoxide dismutase 1 tHcy total homocysteine TIMP-1 tissue inhibitor of metalloproteinase-1 TNF-α tumor necrosis factor-α TGF-β1 transforming growth factor-β1 TUNEL terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate biotin nick end-labeling
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