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Inhibiting Interleukin 36 Receptor Signaling Reduces Fibrosis in Mice With Chronic Intestinal Inflammation |
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| Authors: | Kristina Scheibe Christina Kersten Anabel Schmied Michael Vieth Tatjana Primbs Birgitta Carlé Ferdinand Knieling Jing Claussen Alexander C Klimowicz Jie Zheng Patrick Baum Sebastian Meyer Sebastian Schürmann Oliver Friedrich Maximilian J Waldner Timo Rath Stefan Wirtz George Kollias Clemens Neufert |
| Institution: | 1. First Department of Medicine, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany;2. Institute of Pathology, Klinikum Bayreuth, Bayreuth, Germany;3. Institute of Medical Biotechnology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany;4. Department of Pediatrics and Adolescent Medicine, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany;5. iThera Medical GmbH, Munich, Germany;6. Boehringer Ingelheim Pharmaceuticals Inc, Ridgefield, Connecticut;7. Institute of Medical Informatics, Biometry, and Epidemiology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany;8. Biomedical Sciences Research Center Alexander Fleming, Vari, Greece;9. Institute of Human Genetics, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany |
| Abstract: | |
| Keywords: | α-SMA IL36 IBD Disease Progression IL-36 Cytokine Signaling α-SMA α-smooth muscle actin BM bone marrow CD Crohn’s disease DSS dextran sulfate sodium salt ECM extracellular matrix EMT epithelial-to-mesenchymal transition EPCAM epithelial cell adhesion molecule FACS fluorescence-activated cell sorter IBD inflammatory bowel disease IF immunofluorescence ISH in situ hybridization IL interleukin mRNA messenger RNA MMP matrix metalloproteinase TNBS 2 4 6-trinitro benzene sulfonic acid TNF tumor necrosis factor UC ulcerative colitis |
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