| 灵芝对链脲佐菌素诱导糖尿病大鼠肾脏的保护作用及其机制 |
| |
| 引用本文： | 毛春谱,李小毅,林桂芬,李伟.灵芝对链脲佐菌素诱导糖尿病大鼠肾脏的保护作用及其机制[J].山东医药,2008,48(38):1-3. |
| |
| 作者姓名： | 毛春谱 李小毅 林桂芬 李伟 |
| |
| 作者单位： | 1. 苏州大学附属无锡第四医院,江苏无锡,214062
2. 徐州医学院附属医院 |
| |
| 基金项目： | 江苏省中医药局资助项目 |
| |
| 摘 要： | 目的 探讨灵芝(GL)对链脲佐菌素诱导的糖尿病(DM)大鼠肾脏的保护作用及其机制.方法将30只雄性SD大鼠随机均分为对照组、DM组及GL组.腹腔注射链脲佐菌素诱导大鼠造成DM模型,治疗组用GL治疗性灌胃.8周后,用酶联免疫吸附法检测各组大鼠血清高敏C反应蛋白(hs-XRP),免疫组化法检测肾皮质单核细胞趋化蛋白1(MCP-1)蛋白表达.结果 DM组血清hs-CRP、肾小球MCP-1蛋白表达较对照组升高,GL组较DM组减少,病理变化明显好转(P均<0.01).结论 GL可能通过降低hs-CRP、MCP-1表达而减轻炎症反应,起到保护DM大鼠肾脏的作用.
|
| 关 键 词： | 糖尿病 肾性 高敏C反应蛋白 单核细胞趋化蛋白1 |
Protective effect and mechanism of ganoderma lucidum on diabetic nephropathy in streptozotocin-induced rats |
| |
| MAO Chun-pu,LI Xiao-yi,LIN Gui-fen,LI Wei.Protective effect and mechanism of ganoderma lucidum on diabetic nephropathy in streptozotocin-induced rats[J].Shandong Medical Journal,2008,48(38):1-3. |
| |
| Authors: | MAO Chun-pu LI Xiao-yi LIN Gui-fen LI Wei |
| |
| Institution: | MAO Chun-pu1,LI Xiao-yi,LIN Gui-fen,LI Wei(Wuxi Forth Hospital,Suzhou University,Wuxi 214062,P.R.China) |
| |
| Abstract: | Objective To investigate the protective effect and possible mechanisms of ganoderma lucidum(GL) on diabetic nephropathy(DN) in streptozotocin-induced rats.Methods Thirty Sprague-Damly rats were randomly divided into three groups:normal control group(C group),diabetes mellitus group(DM group) and diabetic group treated with ganoderma lucidum(GL group).Diabetic model of rats were induced by perfusing streptozocin into stomach.GL was perfused into stomach in the GL group.8 weeks later,serum high sensitive C-re... |
| |
| Keywords: | diabetes renal high sensitive C-reactive protein monocyte chemoattractant protein-1 |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
