| 急性脑出血患者外周血sFas和sFasL的变化及意义 |
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| 引用本文： | 王兆平,王文静,时鹏,王前友,潘健,马俊芳,吴蕾. 急性脑出血患者外周血sFas和sFasL的变化及意义[J]. 山东医药, 2011, 51(41): 4-6 |
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| 作者姓名： | 王兆平 王文静 时鹏 王前友 潘健 马俊芳 吴蕾 |
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| 作者单位： | 安徽医科大学附属省立医院,合肥,230001 |
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| 基金项目： | 安徽省卫生厅科研课题计划项目(2010C032) |
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| 摘 要： | 目的探讨急性脑出血（ACH）患者可溶性Fas（sFas）和可溶性Fas配体（sFasL）的变化与出血量、部位、形态及ACH病情变化的关系。方法 ACH患者60例为病例组,同期无脑血管疾病体检者30例为对照组。采用ELISA法测定血清sFas和sFasL,并按出血灶大小、部位、形状进行分组,比较各组之间sFas和sFasL差异。结果 ACH组6 h血清sFas低于对照组（P〈0.01）,24 h、2 d、7 d血清sFas高于对照组（P〈0.01）,ACH组6 h、24 h、2 d、7 d血清sFasL高于对照组（P〈0.01）,血清sFas和sFasL峰值与出血灶的大小、部位、形态有关（P均〈0.01）。结论血浆sFas、sFasL的峰值高可能提示ACH患者的出血灶较大、形态不规则和预后较差。
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| 关 键 词： | 脑出血 sFas sFasL 细胞凋亡 |
Changes of levels of sFas and sFasL in acute cerebral hemorrhage and its significance |
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| WANG Zhao-ping,WANG Wen-jing,SHI Peng,WANG Qian-you,PAN Jian,MA Jun-fang,WU Lei. Changes of levels of sFas and sFasL in acute cerebral hemorrhage and its significance[J]. Shandong Medical Journal, 2011, 51(41): 4-6 |
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| Authors: | WANG Zhao-ping WANG Wen-jing SHI Peng WANG Qian-you PAN Jian MA Jun-fang WU Lei |
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| Affiliation: | WANG Zhao-ping,WANG Wen-jing,SHI Peng,WANG Qian-you,PAN Jian,MA Jun-fang,WU Lei(Affiliated Provincial Hospital of Anhui Medical University,Hefei 230001,P.R.China) |
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| Abstract: | Objective To investigate the relationship between the changes of the serum levels of soluble Fas(sFas),soluble Fas-ligand(sFasL) and the size,location and form of hemorrhage and its condition changes in acute cerebral hemorrhage(ACH) patients.Methods Sixty cases of ACH patients were recruited as the experimental group and 30 cases of the volunteers without cerebrovascular disease as the control group.The serum levels of sFas and sFasL were measured by enzyme-linked immunosorbent assay(ELISA) method in both ... |
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| Keywords: | cerebral hemorrhage sFas sFasL apoptosis |
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