| 区域性和全身性给药治疗重症急性胰腺炎的临床研究 |
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| 引用本文： | 钱祝银,刘训良,苗毅,冯跃良,徐泽宽,戴存才,蒋奎荣,李强,吴峻立,杜竞辉,李麟荪,施海兵.区域性和全身性给药治疗重症急性胰腺炎的临床研究[J].胰腺病学,2001,1(1):40-42. |
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| 作者姓名： | 钱祝银 刘训良 苗毅 冯跃良 徐泽宽 戴存才 蒋奎荣 李强 吴峻立 杜竞辉 李麟荪 施海兵 |
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| 作者单位： | 钱祝银（210002南京,南京医科大学第一附属医院）
刘训良（210002南京,南京医科大学第一附属医院）
苗毅（210002南京,南京医科大学第一附属医院）
冯跃良（210002南京,南京医科大学第一附属医院）
徐泽宽（210002南京,南京医科大学第一附属医院）
戴存才（210002南京,南京医科大学第一附属医院）
蒋奎荣（210002南京,南京医科大学第一附属医院）
李强（210002南京,南京医科大学第一附属医院）
吴峻立（210002南京,南京医科大学第一附属医院）
杜竞辉（210002南京,南京医科大学第一附属医院）
李麟荪（210002南京,南京医科大学第一附属医院）
施海兵（210002南京,南京医科大学第一附属医院） |
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| 摘 要： | 目的探讨区域性和全身性给药对重症急性胰腺炎(severe acute pancreatitis,SAP)的治疗作用.方法自1998年12月至2001年2月收治SAP 67例,入选条件①SAP的临床诊断和分级标准符合1996年制订的第二次方案;②发病时间在72 h内;③暂无急诊手术指征.符合上述条件者共计46例,随机分成两组即组1(区域灌注组)、组2(全身给药组),病例数分别为27例和19例.组1采用改良Sheldinger法经股动脉分别插管至胰十二指肠上动脉及胰大动脉近端、肠系膜上动脉左右支、胃十二指肠动脉和肠系膜上动脉、胰十二指肠上动脉、胰背动脉、胃十二指肠动脉.两组均行深静脉置管.两组除一般支持治疗外,组1经股动脉插管持续予生长抑素14肽、抗生素及血管活性药物等,时间为5～7 d.而组2则采用静脉给药的方法给予上述药物.结果两组平均住院时间分别为(14.3±2.2)d和(28.4±4.3)d,感染发生率为14.8%和52.6%,治愈率为96.3%和57.9%,统计分析均有显著差异(P＜0.01).结论区域灌注对SAP的治愈率高于常规静脉给药,并在防止感染发生及SAP重型化方面优于全身给药组.
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| 关 键 词： | 重症急性胰腺炎 临床研究 治疗 区域灌注疗法 |
| 修稿时间： | 2001年8月20日 |
Clinical Research of Continuous Regional Intra-arterial infusion and Whole Body infusion in the Treatment to Severe Acute Pancretitis |
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| QIAN Zhuyin,LIU Xunliang,MIAO Yi,et al..Clinical Research of Continuous Regional Intra-arterial infusion and Whole Body infusion in the Treatment to Severe Acute Pancretitis[J].Chinese JOurnal of Pancreatology,2001,1(1):40-42. |
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| Authors: | QIAN Zhuyin LIU Xunliang MIAO Yi |
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| Institution: | QIAN Zhuyin,LIU Xunliang,MIAO Yi,et al.Department of General Surgery,First Affiliated Hospital of Nanjing Medical University,Nanjing 210029,China |
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| Abstract: | Objective To study the therapeutic effects of continuous regional intra-arterial infusion (CRI) and Whole body infusion in the treatment to severe acute pancreatitis (SAP). Methods 46 cases of SAP were divided into two groups randomly: group 1(CRI, 27 cases) and group 2(control group, 19 cases). The Sheldinger's method was used to insert a catheter into the pancreatic regional artery, and irrigate the sandostatin and antibiotics by pump for 24hs through group 1. The same drugs were given by vein through group 2. Results In group 1, the abdominal pain of all patients was apparently released after 24hs and disappeared after 7~12 days, and total 26 patients were cured in the end. While in group 2 it lasted for a longer time, and only after 5~7 days treatment it began to release. Conclusions CRI in the treatment to SAP can hold back the development of pancreatic infection and reduce the therapeutic time. And it has better therapeutic effects than the whole body infusion. |
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| Keywords: | Pancreatitis Regional intra-artetial infusion Treatment |
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