| 脂联素对糖尿病大血管病变保护作用的研究进展 |
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| 引用本文： | 蔡清颜.脂联素对糖尿病大血管病变保护作用的研究进展[J].国外医学：内科学分册,2008,35(6). |
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| 作者姓名： | 蔡清颜 |
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| 作者单位： | 福建医科大学附属第二医院内分泌科 福建泉州362000 |
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| 摘 要： | 脂联素是一种脂肪细胞特异性蛋白。脂联素及其基因多态性与糖尿病大血管病变等的发生有密切的关系,脂联素通过抑制血管内皮细胞炎症及黏附、巨噬细胞向泡沫细胞转化、血管平滑肌细胞的增殖移行以及改善糖脂代谢,影响动脉粥样硬化的形成,发挥心血管保护作用。
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| 关 键 词： | 脂联素 2型糖尿病 大血管病变 动脉粥样硬化 |
The protective effect of adiponectin on diabetic macrovascular diseases |
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| CAI Qing-yan,SHI Ya-xiong.The protective effect of adiponectin on diabetic macrovascular diseases[J].Foreign Medical Sciences(Section of Internal Medicine),2008,35(6). |
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| Authors: | CAI Qing-yan SHI Ya-xiong |
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| Institution: | CAI Qing-yan,SHI Ya-xiong.Department of Endocrinology,The Second Affiliated Hospital of Fujian Medical University,Quanzhou 362000,China |
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| Abstract: | Adiponectin is a specific plasma protein secreted by adipocytes.Adiponectin and its genetic polymorphisms are close relative to diabetic macrovascular diseases.Adiponectin can suppress inflammation and adhesion of vascular endothelial cells,differentiation of macrophages into foam cells and proliferation of smooth muscle cells.Adiponectin can also improve glucose and lipid metabolism.In summary,adiponectin offers protection against cardiovascular disease through its anti-atherosclerosis. |
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| Keywords: | Adiponectin Type 2 diabetes Macrovascular diseases Atherosclerosis |
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