| 血清单核细胞趋化蛋白-1水平与新诊断2型糖尿病和糖耐量减低的相关性研究 |
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| 引用本文： | 王美宁,何海宁,黄勇奇,蒋杰球,唐智清,刘巧玲,陈冰.血清单核细胞趋化蛋白-1水平与新诊断2型糖尿病和糖耐量减低的相关性研究[J].中华糖尿病杂志,2013(12):1057-1059. |
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| 作者姓名： | 王美宁 何海宁 黄勇奇 蒋杰球 唐智清 刘巧玲 陈冰 |
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| 作者单位： | [1]广西南宁市第一人民医院内科,530022 [2]南方电网公司医务所 ,530022 [3]广西医科大学生化教研室 ,530022 [4]广西医科大学第一附属医院检验科,530022 |
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| 基金项目： | 广西自然科学基金（桂科自0640198） |
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| 摘 要： | 目的 探讨血清单核细胞趋化蛋白-1 （MCP-1）水平与T2DM、IGT及其危险因素的相关性.方法 检测新诊断T2DM患者32例、IGT患者46例和健康（NC）者111名血清MCP-1水平及其他生化指标,分析血清MCP-1与T2DM、IGT及其危险因素的相关性.结果 T2DM、IGT组血清MCP-1水平高于NC组（P＜0.01）.MCP-1与WHR、TC、胰岛素抵抗指数（HOMA-IR）呈正相关,与年龄、BMI、血压、FPG、2hPG和HbA1c无相关性.结论 血浆MCP-1水平与T2DM、IGT均有相关性,与WHR、TC和HOMA-IR均独立相关.MCP-1可能对T2DM和IGT发病有影响.
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| 关 键 词： | 单核细胞趋化蛋白-1 糖尿病 2型 糖耐量减低 |
Association of serum monocyte chemoattractant protein-1 concentration and with newly diagnosed type 2diabetes and impaired glueose tolerance |
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| Institution: | WANG Mei-ning,HE Hai-ning HUANG Yong-qi( 1.Department of Internal Medicine, Na 1 People＇s Hospital of Nanning City, Nanning 530022, China;) |
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| Abstract: | Objective To explore whether serum monocyte chemoattractant protein-1 （MCP-1）concentration is associated with T2DM,IGT and its relative risk factors.Methods Serum MCP-1 and biochemical characteristics were detected in 32 few oriset of T2DM,46 IGT patients and 111 normal control （NC） subjects.BMI,WHR,HOMA-IR and biochemical parameters were calculated.The correlation of serum MCP-1 with T2DM,IGT and risk factors were analyzed.Results Serum MCP-1 level was higher in T2DM and IGT groups than in NC group （P＜0.01）.MCP-1 was positively correlated with WHR,TC and HOMA-IR.There was no correlation of MCP-1 with age,BMI,blood pressure,FPG,2 hPG and HbA1c.Conclusion Serum MCP-1 level is related with T2DM and IGT.It is independently associated with WHR,TC and HOMA-IR.MCP-1 might affect T2DM and IGT development. |
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| Keywords: | Monocyte chemoattractant protein-1 （MCP-1） Diabetes mellitus type 2 Impaired glucose tolerance（IGT） |
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