| 糖尿病大鼠心肌肾上腺髓质素表达及依那普利的干预效应 |
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| 引用本文： | 徐春生,李志梁,张桦,严全能,傅强,吴宏超,唐朝枢.糖尿病大鼠心肌肾上腺髓质素表达及依那普利的干预效应[J].中华糖尿病杂志,2006,14(6):466-467. |
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| 作者姓名： | 徐春生 李志梁 张桦 严全能 傅强 吴宏超 唐朝枢 |
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| 作者单位： | [1]南方医科大学附属珠江医院心内科,广州510282 [2]南方医科大学附属珠江医院内分泌利,广州510282 [3]北京大学医学院心血管研究所,广州510282 |
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| 基金项目： | 国家重点基础研究发展计划(973计划) |
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| 摘 要： | 采用RT-PCR及原位杂交观察糖尿病大鼠心肌肾上腺髓质素（ADM）表达水平及依那普利的干预作用。发现糖尿病大鼠心肌ADM表达增强，依那普利减低其表达。ADM在糖尿病心肌病变的发生中町能发挥重要作用。
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| 关 键 词： | 糖尿病 实验性 肾上腺髓质素 依那普利 |
| 收稿时间： | 2005-03-09 |
| 修稿时间： | 2005-03-09 |
The myocardial adrenomedullin expression in diabetic rats and the therapeutic effect of enalapril |
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| XU Chun-sheng, LI Zhi-liang, ZHANG Hua , et al.The myocardial adrenomedullin expression in diabetic rats and the therapeutic effect of enalapril[J].CHINESE JOURNAL OF DIABETES MELLITUS,2006,14(6):466-467. |
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| Authors: | XU Chun-sheng LI Zhi-liang ZHANG Hua |
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| Institution: | Department of Cardiology, Zhujiang Hospital, Nan fang Medical University, Guangzhou 510282 ,China |
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| Abstract: | RT-PCR and in-situ hybridization(ISH) were performed to observe the myocardial adrenomedullin(ADM) and its mRNA expression level and the therapeutic effect of enalapril treat-ment in STZ-induced diabetic rats.Results indicated that the myocardial ADM expression level in-creased in diabetic rats and enalapril intervention could reverse this process,suggesting that ADM may play an important role in the pathogenesis of diabetic cardiomyopathy. |
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| Keywords: | Diabetes experimental Adrenomedullin Enalapril |
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