| 神经肽Y对心肌蛋白质合成的影响及其意义 |
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| 引用本文： | 王涛,韩启德,杨丽华,王宪,陈明哲.神经肽Y对心肌蛋白质合成的影响及其意义[J].中国循环杂志,1991(5). |
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| 作者姓名： | 王涛 韩启德 杨丽华 王宪 陈明哲 |
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| 作者单位： | 北京医科大学第三医院心血管研究室
(王涛，韩启德，杨丽华，王宪)，北京医科大学第三医院心血管研究室(陈明哲) |
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| 摘 要： | 用~3H-亮氨酸参入法与放射免疫分析法分别测定大鼠心肌蛋白质合成速度与心脏组织中神经肽Y(NPY)含量。结果显示NPY能显著促进心肌蛋白质合成,其最大效应较去甲肾上腺素(NE)大35%,所需浓度是NE的1/100。心肌梗塞后非梗塞区组织内NPY的含量在2天时无显著改变,15天时则降低71%,提示2～15天期间该区域NPY释放增加,此为非梗塞区心肌肥大的机制之一
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| 关 键 词： | 神经肽Y 蛋白质合成 心肌肥大 心肌梗塞 |
EFFECT AND SIGNIFICANCE OF NEUROPEPTIDE Y ON SYNTHESIS OF MYOCARDIAL PROTEIN |
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| Wang Tao,Han Qide,Yang Lihua,et al..EFFECT AND SIGNIFICANCE OF NEUROPEPTIDE Y ON SYNTHESIS OF MYOCARDIAL PROTEIN[J].Chinese Circulation Journal,1991(5). |
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| Authors: | Wang Tao Han Qide Yang Lihua |
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| Institution: | Wang Tao,Han Qide,Yang Lihua,et al. Cardiovascular Laboratory,The Third Hospital,Beijing Medical University,Bei jing |
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| Abstract: | The rate of myocardial protein synthesis and the cardiac content of neuropeptide Y (NPY) in rats were measured by ~(?)H-leucine incorporation and radioimmunoassay respectively. The results showed that NPY could increase the rate of myocardial protein synthesis. The maximal effect of NPY was about 35% greater than that of norepinephrine (NE), and NPY was also 100-fold more potent than NE. After experimental myocardial infarction, the NPY content in non-infarcted area was not changed on the third day, but decreased to 71% of control on the 16th day. It suggests that the release of NPY during that period is increased, which might be one of the causes of myocardial hypertrophy of the non-infarcted area. |
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| Keywords: | Neuropeptide Y Protein synthesis Myocardial hypertrophy Myocardial infarction |
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