| 组织因子与冠心病 |
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| 引用本文： | 夏大胜,王佩显.组织因子与冠心病[J].中国心血管杂志,2003,8(4):294-297. |
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| 作者姓名： | 夏大胜 王佩显 |
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| 作者单位： | 1. 天津市第一中心医院心内科,天津,300192
2. 天津医科大学总医院,天津,300052 |
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| 摘 要： | 组织因子作为因子 F /F a的细胞膜表面受体 ,是生理凝血过程中最重要的启动因子 ,许多炎性介质能诱导单核细胞、巨噬细胞、平滑肌细胞和血管内皮细胞表达组织因子。组织因子通过介导凝血激活形成血栓以及促进平滑肌细胞增殖和移行影响冠心病的发生和发展。本文对组织因子与动脉粥样硬化、血管成形术后再狭窄 ,心肌缺血及心肌缺血 -再灌注损伤等冠心病相关病理过程作一综述
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| 关 键 词： | 组织因子 冠状动脉病 |
| 文章编号： | 1007-5410(2003)04-0294-04 |
| 修稿时间： | 2002年6月5日 |
Tissue factor and coronary heart disease |
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| XIA Da-sheng ,WANG Pei-xian ..Tissue factor and coronary heart disease[J].Chinese Journal of Cardiovascular Medicine,2003,8(4):294-297. |
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| Authors: | XIA Da-sheng WANG Pei-xian |
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| Institution: | XIA Da-sheng 1,WANG Pei-xian 2.1. Department of Cardiology,the First Central Hospital,Tianjin 300192,China,2. The General Hospital of Tianjin Medical University,Tianjin 300052,China |
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| Abstract: | Tissue factor(TF) is receptor for factor FⅦ/ FⅦa on the cell surface. It is an important initiator of the coagulation cascade situated within the vessel wall.Several mediators involved in the process of atherosclerotic plaque formation are capable of inducing expression of TF in cells such as monocytes, macrophages, smooth muscle cells and endothelial cells. TF plays pivotal roles in thrombus formation and facilitates smooth muscle cell proliferation as well as migration, which is an important contribution in the pathogenesis of coronary artery disease. This review presents the current knowledge on the role of TF in atherosclerosis, restenosis after angioplasty and myocardial ischemia as well as myocardial injury during postischemic reperfusion. |
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| Keywords: | Tissue factor Coronary artery disease |
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