淋巴细胞/单核细胞比值预测老年结肠高危腺瘤的价值

目的本研究旨在观察老年人群中结肠高危腺瘤病人淋巴细胞/单核细胞比值(LMR)和其他炎症因子的变化,探讨LMR对老年结肠高危腺瘤的预测价值。方法纳入157例行结肠镜检查的老年病人并收集相关临床资料。采用Logistic回归分析高危腺瘤的危险因素,采用ROC曲线评价LMR对结肠高危腺瘤的预测价值。结果单因素分析表明,单核细胞计数、LMR和中性粒细胞/淋巴细胞比值(NLR)是高危腺瘤的影响因素(P<0.05)。Logistic回归分析显示,LMR是高危腺瘤的独立危险因素。ROC曲线分析表明,LMR预测高危腺瘤的灵敏度为65.6%,特异性为70.4%(AUC=0.720,P<0.001),LMR最佳截断值为4.49。结论LMR与老年结肠高危腺瘤有关,可作为预测结肠高危腺瘤新的生物标志物。

Lymphocyte-to-monocyte ratio in predicting high-risk colon adenomas in elderly patients

Objective To observe the changes of lymphocyte-to-monocyte ratio(LMR)and other inflammatory factors in the elderly patients with high-risk colon adenomas,and to investigate the predictive value of LMR for high-risk colon adenomas.Methods The clinical data of 157 elderly patients who underwent colonoscopy were retrospectively collected and analyzed.Logistic regression analysis was performed to identify the risk factors of high-risk colon adenomas.Receiver operating characteristic(ROC)curve was used to evaluate the predictive efficiency of LMR for high-risk colon adenoma.Results Univariate analysis showed that monocyte count,LMR and neutrophil-to-lymphocyte ratio(NLR)were influencing factors for high-risk adenomas(P<0.05).Logistic regression analysis revealed that LMR was an independent risk factor for high-risk adenomas.ROC curve analysis showed that LMR could predict high-risk adenomas with a critical LMR of 4.49,with sensitivity of 65.6%,specificity of 70.4%,area under the curve(AUC)of 0.720(P<0.001).Conclusions Lower LMR is associated with high-risk colon adenomas and it can be used as a new biomarker to diagnose high-risk colon adenomas in the elderly patients.