| 药对黄连、吴茱萸对高血压大鼠血压和血浆ET、CGRP的影响 |
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| 引用本文： | 卜宪峥,吴华芹,胡元会,褚瑜光,宋庆桥,王师菡.药对黄连、吴茱萸对高血压大鼠血压和血浆ET、CGRP的影响[J].中西医结合心脑血管病杂志,2011,9(9):1079-1080. |
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| 作者姓名： | 卜宪峥 吴华芹 胡元会 褚瑜光 宋庆桥 王师菡 |
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| 作者单位： | 1. 中国软件与技术服务股份有限公司,102200
2. 中国中医科学院广安门医院,100053 |
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| 摘 要： | 目的观察药对黄连、吴茱萸对自发性高血压大鼠(SHR)血压和血管活性物质内皮素(ET)、降钙素基因相关肽(CGRP)含量的影响。方法将24只SHR随机分为模型组(Model组)、硝苯地平组(Nif组)、连萸药对组(LY组),每组8只,以正常WKY大鼠为对照组(WKY组),8只,共4组。WKY组和Model组予以生理盐水,Nif组予以硝苯地平溶液,中药组予以相应配伍剂量的浓煎剂,连续灌胃4周,测量大鼠灌胃前和灌胃4周末大鼠尾动脉的收缩压。第4周末同时测定大鼠血浆中ET、CGRP的含量。结果与Model组比较,中药组大鼠4周后血压水平明显降低(P<0.05),血浆ET含量降低(P<0.05),CGRP的含量明显升高(P<0.05),但与Nif组相比无统计学意义。结论药对黄连、吴茱萸对SHR有明显的降压作用,其机制可能与降低血浆中ET的含量,增加CGRP的含量有关。
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| 关 键 词： | 黄连 吴茱萸 高血压 内皮素 降钙素基因相关肽 高血压病 大鼠 |
Effect of Drug Pair of Coptis Chinensis and Evodia Rutatecarpa on Blood Pressure,Plasma Endothelin and Calcitonin Gene - related Peptide in Spontaneous Hypertension Rats |
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| Bu Xianzheng,Wu Huaqin,Hu Yuanhui,et al China National Software , Service Co.Ltd.Effect of Drug Pair of Coptis Chinensis and Evodia Rutatecarpa on Blood Pressure,Plasma Endothelin and Calcitonin Gene - related Peptide in Spontaneous Hypertension Rats[J].Chinese Journal of Integrative Medicine on Cardio-/Cerebrovascular Disease,2011,9(9):1079-1080. |
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| Authors: | Bu Xianzheng Wu Huaqin Hu Yuanhui China National Software Service CoLtd |
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| Institution: | Bu Xianzheng,Wu Huaqin,Hu Yuanhui,et al China National Software and Service Co.Ltd(Beijing 102200) |
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| Abstract: | Objective To investigate the effects of drug pair of coptis chinensis and evodia rutatecarpa on blood pressure,the content of plasma endothelin(ET),and calcitonin gene-related peptide(CGRP) in spontaneous hypertension rats(SHR).Methods Twenty-four SHR were randomly divided into model group(n=8),nifedipine group(n=8) given nifedipine,and Lianyu decoction group(n=8) given Lianyu oral liquid by continuously gavages.Eight normal Wistar-Kyoto rats(WKY) were as control(WKY group).WKY group and Model group were gi... |
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| Keywords: | coptis chinensis evodia rutatecarpa blood pressure endothelin calcitonin gene-related peptide hypertension rats |
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