补阳还五汤加味联合胞磷胆碱注射液治疗血管性痴呆的疗效观察

目的观察补阳还五汤加味联合胞磷胆碱注射液治疗血管性痴呆的临床疗效。方法将80例辨证为气虚血瘀证的血管性痴呆患者随机分为治疗组和对照组，每组40例。两组基础治疗相同，对照组给予尼莫地平片口服，治疗组给予补阳还五汤加味煎服，胞磷胆碱注射液静脉输注治疗。两组在治疗前后分别进行简易精神状态量表（MMSE）及日常生活能力量表（ADL）评分。结果治疗组总有效率为97．5％，明显优于对照组的77．5%（P〈0．05）。两组治疗后MMSE和ADL评分较治疗前明显提高（P〈0．01），但治疗组明显优于对照组（P〈0．05或P〈0．01）。结论补阳还五汤加味联合胞磷胆碱注射液治疗血管性痴呆疗效显著，能够显著改善患者认知功能及日常生活能力。

Efficacy of Buyang Huanwu Decoction and Citicoline Injection in Treatment of Vascular Dementia

Objective To observe clinical efficacy of Buyang Huanwu decoction（t3HD） and citicotine injection in treatment of vascular dementia（VD）. Methods Eighty patients with VD （MMSE score between 10 to 23 ） were randomly divided into two groups： Experimental group （n=40） treated by BHD plus citicoline injection,and control group（n=40） treated by routine treatment plus nimodipine tablets. The scales of MMSE and ADL were respectively used to assess patients＇ cognitive function,ability of daily living at both baseline and after 3 weeks＇ treatment. Results The total clinical effective rate was97.5% in experimental group,which was significantly higher than that in control group（87.5%, P〈0.05）. The scales of MMSE and ADL were increased after treatment in two groups,which in experimental were obviously higher than that of control group（P〈0.05 or P〈0.01）. Conclusion BHD and citicoline injection was of obvious efficacy in treating VD,which could improve cognition and activities of daily living in patients.