| 超敏C反应蛋白和脂蛋白a测定在冠状动脉植入药物洗脱支架后发生支架内再狭窄的意义 |
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| 引用本文： | 王审,刘学波,戴宇翔,李晨光,葛均波.超敏C反应蛋白和脂蛋白a测定在冠状动脉植入药物洗脱支架后发生支架内再狭窄的意义[J].心脑血管病防治,2009,9(5):334-335. |
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| 作者姓名： | 王审 刘学波 戴宇翔 李晨光 葛均波 |
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| 作者单位： | 1. 温州医学院附属温岭医院心内科,浙江,温岭,317500
2. 复旦大学附属中山医院心脏内科,上海,200032 |
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| 摘 要： | 目的:探讨超敏C反应蛋白(hs-CRP)和脂蛋白a(LP(a))测定在冠状动脉植入药物洗脱支架后发生支架内再狭窄的意义。方法:在上海中山医院复查冠脉造影的486例患者资料进行了回顾性分析。结果:发生再狭窄的患者第二次冠脉造影前超敏CRP水平(3.1±3.7mg/L比1.0±1.4mg/L,P<0.01)和Lp(a)水平(271±267.5mol/L比167.7±122.3mol/L,P<0.01)均较无再狭窄组增高;多因素Logistic逐步回归分析显示药物洗脱支架术后支架内再狭窄与超敏CRP水平(P=0.002,OR=1.655,95%CI:1.195～2.291)、Lp(a)水平(P=0.012,OR=1.004,95%CI:1.001～1.007)成正相关。结论:对于药物洗脱支架植入术后的患者,控制超敏CRP、Lp(a)水平是减少支架内再狭窄的重要因素。
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| 关 键 词： | 冠状动脉疾病 药物洗脱支架 支架内再狭窄 危险因素 脂蛋白 |
Hs-CRP and Lipoprotein a as Risk Factors of In-steat Restenosis after Coronary Drug Eluting Stenting |
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| Institution: | WANG Shen, LIU Xue-bo, DAI Yu-xiang, et al. (Department of Cardiology, The Affiliated Wenling Hospital of Wenzhou medical college, Zhejiang 317500, China) |
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| Abstract: | Objective To explore the role of sensitivity C-reactive protein（hs-CRP）and lipoprotein（a） in in-stent restenosis（ISR） after coronary drug eluting stent. Methods The data of 486 patients who did coronary angiography during December 25 2007 to December 10 2008 were retrospective analyzed. Results The levels of hs-CRP（ 3.1 ± 3.7mg/L） and Lp（a） （271 ±267.5mol/L） in ISR group were significantly higher than those in no- restenosis group（ 1.0 ±1.4mg/L and 167.7 ± 122.3mol/L, respectively）. Multiple logistic stepwise regression analysis showed that there was a positive correlation among the levels of hs-CRP（ P = 0. 002, OR = 1. 655, 95% CI： 1. 195 - 2.291 ）and Lp（a） （ P = 0.012. OR = 1.004, 95% CI： 1.001 - 1.007） and ISR. Conclusions Control the levels of hs-CRP and Lp（a） after coronary drug eluting stent is an important way to prevent restenosis. |
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| Keywords: | Coronary artery disease Drug eluting stent In-stent restenosis Sensitivity C-reactive Protein Lipoprotein（a） |
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