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Exercise-induced AMPK activity in skeletal muscle: Role in glucose uptake and insulin sensitivity |
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| Authors: | Martin Friedrichsen Brynjulf Mortensen Christian Pehmøller Jesper B Birk Jørgen FP Wojtaszewski |
| Institution: | 1. Molecular Physiology Group, The August Krogh Centre, Department of Exercise and Sport Sciences, University of Copenhagen, Denmark;2. Department of Diabetes and Metabolism, Rigshospitalet, Copenhagen, Denmark;3. Steno Diabetes Center, Gentofte, Denmark |
| Abstract: | The energy/fuel sensor 5′-AMP-activated protein kinase (AMPK) is viewed as a master regulator of cellular energy balance due to its many roles in glucose, lipid, and protein metabolism. In this review we focus on the regulation of AMPK activity in skeletal muscle and its involvement in glucose metabolism, including glucose transport and glycogen synthesis. In addition, we discuss the plausible interplay between AMPK and insulin signaling regulating these processes. |
| Keywords: | Aa amino acids ACCβ acetyl-CoA carboxylase β AICAR 5-aminoimidazole-4-carboxamide ribonucleoside AMPK 5&prime -AMP-activated protein kinase CaMKK calcium/calmodulin-dependent protein kinase kinase CBM carbohydrate binding motif CBS cystathionine-β-synthase GLUT4 glucose transporter isoform 4 GS glycogen synthase IL-6 interleukin-6 KD kinase deficient KO knock-out LKB1 liver kinase B1 NO nitric oxide NOS nitric oxide synthase PAS phospho-Akt-substrate PP protein phosphatase PPARβ peroxisome proliferator-activated receptor β SNARK sucrose non-fermenting AMPK-related kinase TBC1D4 TBC1 domain family member 1 TBC1D4 TBC1 domain family member 4 T2DM type 2 diabetes mellitus |
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