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HAART对HIV辅助受体的影响研究
引用本文:郭彩萍,田亚坤,焦艳梅,易银,张薇,代丽丽,吴昊.HAART对HIV辅助受体的影响研究[J].传染病信息,2011,24(6):339-341.
作者姓名:郭彩萍  田亚坤  焦艳梅  易银  张薇  代丽丽  吴昊
作者单位:首都医科大学附属北京佑安医院感染科,100069
基金项目:国家自然科学基金,艾滋病研究北京市重点实验室项目
摘    要:目的 探讨在HIV-1感染过程中,高效抗反转录病毒治疗(highly active antiretroviral therapy,HAART)与病毒嗜性的关系.方法 从治疗前和治疗24周患者的外周血单个核细胞中提取基因组DNA,克隆HIV-1 env区的C2-V5区并测序.基于V3区氨基酸序列,通过Gen02pheno...

关 键 词:HIV-1  DNA  趋化因子受体

Effect of HAART on HIV co-receptor
GUO Cai-ping,TIAN Ya-kun,JIAO Yan-mei,YI Yin,ZHANG Wei,DAI Li-li,WU Hao.Effect of HAART on HIV co-receptor[J].Infectious Disease Information,2011,24(6):339-341.
Authors:GUO Cai-ping  TIAN Ya-kun  JIAO Yan-mei  YI Yin  ZHANG Wei  DAI Li-li  WU Hao
Institution:(Department of Infectious Diseases,Beijing You'an Hospital,Capital Medical University,Beijing 100069,China )
Abstract:Objective To investigate the relationship between highly active antiretroviral therapy(HAART) and viral tropism during HIV-1 infection.Methods Genomic DNA was extracted from peripheral blood mononuclear cells(PBMCs) of patients before HAART and at week 24 of HAART.C2-V5 regions of HIV-1 env were cloned and sequenced.Co-receptor tropism was predicted by Geno2pheno and PSSM software based on amino acid sequence of V3 region.Results After HAART,viral loads were declined in viral strains carrying CXCR4 and CCR5 receptors.At week 24 of HAART,expression rate of R5 virus was higher than that of X4 virus,and positive charge and net charge significantly reduced(P〈0.05).Conclusions HAART can effectively suppress X4 and R5 strains,with priority to suppressing X4 strains.This helps to improve the prognosis of the disease,and provide an evidence for the patients failing treatment with CCR5 inhibitor to develop new regimens.
Keywords:HIV-1  DNA  receptors  chemokine
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