不同人群中新型呼肠病毒既往感染状况调查 |
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引用本文: | 胡燕,貌达,刘泽,姜棋予,谢国明,白冰珂.不同人群中新型呼肠病毒既往感染状况调查[J].传染病信息,2015(4):207-209. |
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作者姓名: | 胡燕 貌达 刘泽 姜棋予 谢国明 白冰珂 |
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作者单位: | 1. 解放军第三〇二医院实验技术研究保障中心, 北京,100039;2. 中国食品药品检定研究院艾滋病性病病毒疫苗室, 北京,100050 |
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基金项目: | 国家自然基金青年基金(81000735) |
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摘 要: | 目的调查不同人群中新型呼肠病毒既往感染情况。方法选取健康人群以及手足口病、腹泻、麻疹、乙型肝炎等患者的血清标本,利用微量中和试验检测其血清标本中新型呼肠病毒IgG抗体。结果中和试验结果表明,健康人群中新型呼肠病毒IgG抗体阳性率为29.90%,抗体滴度的中位数为1:32;手足口病患者中抗体阳性率为70.83%,抗体滴度的中位数为1:64;乙型肝炎和麻疹患者抗体阳性率分别为90.22%和90.70%,抗体滴度的中位数均为1:128;腹泻患者中抗体阳性率和抗体滴度的中位数均最高,分别为100%和1:256。结论健康人群与不同疾病患者中薪型呼肠病毒特异性IgG抗体阳性率及滴度存在显著差异。
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关 键 词: | 呼肠病毒科感染 血清分型 中和试验 |
Serological survey of past infection with a novel reovirus in different populations |
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Abstract: | Objective To evaluate the prevalence of past infection with a novel reovirus in different populations. Methods The serum samples were taken from 97 healthy people and 219 patients with hand, foot and mouth disease (HFMD), diarrhea, measles and hepatitis B treated in our hospital. The prevalence of the novel reovirus-specific IgG antibody in sera was detected by using a neutraliza-tion assay. Results The neutralization assay demonstrated that the positive rates of the novel reovirus-specific IgG antibody were 29.90%in healthy controls, 70.83%in HFMD group, 90.22%in hepatitis B group, 90.70%in measles group and 100%in diarrhea group, and the median IgG antibody titers were 1∶32, 1∶64, 1∶128, 1∶128 and 1∶256 in those groups respectively. Conclusions The positive rates and titers of a novel reovirus-specific IgG antibody are significantly different between the healthy population and patients with different diseases. |
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Keywords: | reoviridae infections serotyping neutralization tests |
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