肝纤维化无创诊断研究进展

慢性肝脏疾病是一个全球性的重大公共健康问题,肝纤维化是疾病发展中关键病理阶段之一,其分期及程度对肝病的治疗和预后起决定性作用。近年来,随着新型无创诊断方法的不断涌现,其在很大程度上取代了肝穿刺活检来评估慢性肝病的严重程度。这些方法大致可分为以下两类:基于血清生物标志物的"生物学"方法和基于弹性成像技术的"物理学"方法。本文将对常见肝病中肝纤维化的无创诊断方法的相关研究进展进行简要综述。

Advance on non-invasive diagnosis of liver fibrosis

Chronic liver disease is a major problem in field of global public health. Liver fibrosis is one of the most critical pathological stages in this disease progression. Its stage and severity play a crucial role in the therapeutic effect and prognosis of liver disease. With the emergence of new non-invasive diagnostic methods within recent years, non-invasive methods are largely used as an alternative to liver biopsy to assess the severity of chronic liver disease. These methods are roughly divided into 2 categories: "biological"methods based on serum biomarkers; "physics" methods based on elastography. This study aims to briefly review recent advances on non-invasive diagnostic methods for liver fibrosis in common liver diseases.