| 内脂素与ST段抬高型心肌梗死患者PPCI术后新发心房颤动的关系 |
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| 引用本文： | 胡恒境,刘启明,谢忠,周丹,唐志晗,屈顺林,张弛,吴洁,姜志胜.内脂素与ST段抬高型心肌梗死患者PPCI术后新发心房颤动的关系[J].中国动脉硬化杂志,2018,26(7):678-684. |
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| 作者姓名： | 胡恒境 刘启明 谢忠 周丹 唐志晗 屈顺林 张弛 吴洁 姜志胜 |
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| 作者单位： | 南华大学附属第一医院心内科;南华大学心血管疾病研究所动脉硬化学湖南省重点实验室;中南大学湘雅二医院心内科 |
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| 基金项目： | 国家自然科学基金(81470435,81700306)；中国博士后科学基金(2017M622588) |
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| 摘 要： | 目的循环内脂素(visfatin)水平高低与急性ST段抬高型心肌梗死(STEMI)患者的全因死亡发生具有相关性。据此推测,较高的内脂素可能与主要不良心血管事件(MACE)的发生有关,并增加急诊经皮冠状动脉介入治疗(PPCI)STEMI患者心房颤动(AF)的发生率。方法 604例接受PPCI治疗的STEMI患者纳入研究。使用ELISA法测量术前血浆内脂素浓度。随访1年,记录术后AF及MACE发生率,并分析血浆内脂素水平与MACE、新发AF之间的关系。结果在604例患者中,新发AF 42例(6.95%)。与术后无AF患者相比,新发AF患者1年MACE发生率升高(45.24%比19.57%,P0.05)。此外,与血浆低水平内脂素(≤14.5μg/L)患者相比,血浆高水平内脂素(14.5μg/L)患者拥有更高的MACE发生率(31.02%比9.56%,P0.001)和新发AF率(10.24%比2.94%,P0.001)。多因素Cox风险回归模型分析显示,血浆内脂素水平为PPCI术后1年新发AF的独立预测因素(HR 1.51,95%CI 1.03~2.23,P=0.021)。结论在行PPCI的STEMI患者中,血浆内脂素水平高低与MACE的发生有关,并且与新发AF率呈正相关。
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| 关 键 词： | 内脂素 心房颤动 急性ST段抬高型心肌梗死 主要不良心血管事件 |
| 收稿时间： | 2018/2/21 0:00:00 |
| 修稿时间： | 2018/5/9 0:00:00 |
Relationship between visfatin and new-onset atrial fibrillation after PPCI in patients with ST elevation myocardial infarction |
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| HU Hengjing,LIU Qiming,XIE Zhong,ZHOU Dan,TANG Zhihan,QU Shunlin,ZHANG Chi,WU Jie and JIANG Zhisheng.Relationship between visfatin and new-onset atrial fibrillation after PPCI in patients with ST elevation myocardial infarction[J].Chinese Journal of Arteriosclerosis,2018,26(7):678-684. |
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| Authors: | HU Hengjing LIU Qiming XIE Zhong ZHOU Dan TANG Zhihan QU Shunlin ZHANG Chi WU Jie and JIANG Zhisheng |
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| Institution: | Department of Cardiology Lab, the First Affiliated Hospital of University of South China, Hengyang, Hunan 421001, China;Institute of Cardiovascular Disease and Key Lab for Arteriosclerology of Hunan Province, University of South China, Hengyang, Hunan 421001, China,Department of Cardiology/Cardiac Catheterization Lab, the Second Xiangya Hospital, Central South University, Changsha, Hunan 410000, China,Department of Cardiology Lab, the First Affiliated Hospital of University of South China, Hengyang, Hunan 421001, China,Department of Cardiology Lab, the First Affiliated Hospital of University of South China, Hengyang, Hunan 421001, China,Institute of Cardiovascular Disease and Key Lab for Arteriosclerology of Hunan Province, University of South China, Hengyang, Hunan 421001, China,Institute of Cardiovascular Disease and Key Lab for Arteriosclerology of Hunan Province, University of South China, Hengyang, Hunan 421001, China,Institute of Cardiovascular Disease and Key Lab for Arteriosclerology of Hunan Province, University of South China, Hengyang, Hunan 421001, China,Department of Cardiology Lab, the First Affiliated Hospital of University of South China, Hengyang, Hunan 421001, China and Department of Cardiology Lab, the First Affiliated Hospital of University of South China, Hengyang, Hunan 421001, China;Institute of Cardiovascular Disease and Key Lab for Arteriosclerology of Hunan Province, University of South China, Hengyang, Hunan 421001, China |
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