| 急性脑梗死患者血清PAPP-A水平与颈动脉粥样硬化斑块的相关性 |
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| 引用本文： | 王本孝,王俊珺,赵学敏,秦淑国,方开峰,王 鹏.急性脑梗死患者血清PAPP-A水平与颈动脉粥样硬化斑块的相关性[J].中国动脉硬化杂志,2015,23(2):156-160. |
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| 作者姓名： | 王本孝 王俊珺 赵学敏 秦淑国 方开峰 王 鹏 |
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| 作者单位： | 皖北煤电集团总医院;蚌埠医学院第三附属医院神经内科;蚌埠医学院第三附属医院检验科;蚌埠医学院第三附属医院超声科 |
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| 基金项目： | 安徽省淮北市科技局科技人才培育基金项目(20110315) |
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| 摘 要： | 目的探讨急性脑梗死患者妊娠相关血浆蛋白A(PAPP-A)水平与颈动脉粥样硬化斑块的关系。方法应用彩色多普勒超声检查79例急性脑梗死组患者和64例正常对照者的颈动脉斑块及内膜中膜厚度(IMT),同时检测血清PAPP-A水平;将急性脑梗死患者依据颈动脉超声检查结果分为颈动脉无斑块组15例,稳定性斑块组20例,不稳定性斑块组44例,比较各组血清PAPP-A水平。结果急性脑梗死斑块检出率、不稳定性斑块检出率及IMT均显著高于正常对照组(P0.01),血清PAPP-A水平高于正常对照组(P0.05)。在急性脑梗死患者中,不稳定性斑块组血清PAPP-A水平显著高于稳定性斑块组和无斑块组,稳定性斑块组血清PAPP-A水平显著高于无斑块组(P0.01)。线性相关分析显示,急性脑梗死组患者IMT与血清PAPP-A水平有明显相关性(r=0.718,P0.01)。结论颈动脉粥样硬化斑块及其稳定性与脑梗死发生有密切关系;PAPP-A与颈动脉粥样硬化密切相关,可能是不稳定性粥样硬化斑块的血清标志物。
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| 关 键 词： | 妊娠相关血浆蛋白A 急性脑梗死 颈动脉内膜中膜厚度 动脉粥样硬化斑块 |
| 收稿时间： | 2014/6/12 0:00:00 |
Relationship of Serum Levels of Pregnancy-associated Plasma Protein-A with Carotid Atherosclerotic Plaque in Acute Cerebral Infarction |
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| WANG Ben-Xiao,WANG Jun-Jun,ZHAO Xue-Min,QIN Shu-Guo,FANG Kai-Feng,and WANG Peng.Relationship of Serum Levels of Pregnancy-associated Plasma Protein-A with Carotid Atherosclerotic Plaque in Acute Cerebral Infarction[J].Chinese Journal of Arteriosclerosis,2015,23(2):156-160. |
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| Authors: | WANG Ben-Xiao WANG Jun-Jun ZHAO Xue-Min QIN Shu-Guo FANG Kai-Feng and WANG Peng |
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| Institution: | WANG Ben-Xiao;WANG Jun-Jun;ZHAO Xue-Min;QIN Shu-Guo;FANG Kai-Feng;WANG Peng;General Hospital of Wanbei Coal and Electricity Group & Department of Nuerology,the Third Affiliated Hospital of Bengbu Medical College;General Hospital of Wanbei Coal and Electricity Group & Department of Laboratory Medicine,the Third Affiliated Hospital of Bengbu Medical College;General Hospital of Wanbei Coal and Electricity Group & Department of Ultrasonography,the Third Affiliated Hospital of Bengbu Medical College; |
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| Abstract: | |
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| Keywords: | Pregnancy-associated Plasma Protein-A Acute Cerebral Infarction Carotid Intima-media Thickness Atherosclerotic Plaque |
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