妊娠高血压综合征患者血浆中分子物质含量变化及其临床意义

目的探讨中分子物质在妊娠高血压综合征患者血浆中的变化及其临床意义。方法采用改进的紫外吸收法测定82例妊娠高血压综合征患者9、8例正常妊娠妇女及66例正常非妊娠妇女血浆中分子物质含量。结果正常非妊娠妇女血浆中分子物质水平为2.23±0.2 ku/L;正常妊娠妇女分娩前血浆中分子物质水平为2.25±0.23 ku/L,分娩后为2.24±0.24 ku/L;统计全部妊娠高血压综合征患者分娩前血浆中分子物质水平为3.06±0.29ku/L,分娩后为2.86±0.26 ku/L。其中轻度妊娠高血压综合征患者分娩前血浆中分子物质水平为2.72±0.21 ku/L,分娩后48 h为2.55±0.19 ku/L;中度妊娠高血压综合征患者分娩前血浆中分子物质水平为2.97±0.25 ku/L,分娩后48 h为2.76±0.23 ku/L;重度妊娠高血压综合征患者分娩前血浆中分子物质水平为3.20±0.34 ku/L,分娩后48 h为3.12±0.30 ku/L。说明妊娠高血压综合征患者分娩前血浆中分子物质水平比正常非妊娠妇女及正常妊娠妇女分娩前血浆中分子物质水平显著性升高(P<0.05);在轻、中、重度妊娠高血压综合征之间,血浆中分子物质有显著性差别(P<0.01或P<0.05),中分子物质水平越高,妊娠高血压综合征病情越重;三种类型妊娠高血压综合征患者分娩后48h其血浆中分子物质水平都有所回落,分娩前后的血浆中分子物质有显著性差别(P<0.05)。正常妊娠妇女及正常非妊娠妇女血浆中分子物质水平没有显著性差别(P>0.05)。结论中分子物质与妊娠高血压综合征发病学有关,中分子物质可作为判断妊娠高血压综合征病情程度的指标之一。

Changes and Clinical Significances of Middle Molecular Substances Levels in the Plasma of Patients with Pregnancy Induced Hypertension

Aim To study the changes and clinical significances of middle molecular substances(MMS) levels in the plasma of patients with pregnancy induced hypertension(PIH).Methods Plasma MMS concentrations in 82 cases of PIH,98 cases of normal pregnant women and 66 cases of healthy nonpregnant women were measured by an improved ultra-violet ray absorption method.Results Plasma MMS concentrations in healthy nonpregnant women was 2.23±0.20 ku/L,in normal pregnant women were 2.25±0.23 ku/L(prepartum) and 2.24±0.24 ku/L(48 h postpartum),in all PIH were 3.06±0.29 ku/L(prepartum) and 2.86±0.26 ku/L(48 h postpartum),respectively.Plasma MMS contents in mild,moderate,and severe PIH were 2.72±0.21 ku/L(prepartum) and 2.55±0.19 ku/L(48 h postpartum),2.97±0.25 ku/L(prepartum) and 2.76±0.23 ku/L(48 h postpartum),3.20±0.34 ku/L(prepartum)and 3.12±0.30 ku/L(48 h postpartum),respectively.The results showed that plasma MMS concentrations were significantly higher in PIH group than those in normal pregnant women group and healthy nonpregnant women group respectively(p<0.01).There was significant difference among plasma MMS levels from patients with mild,moderate,and severe PIH(p<0.01 or p<0.05).The higher plasma MMS levels,the worser state of PIH.The plasma MMS levels decreased significantly in 48 h post partum in PIH group(p<0.05).There was no obvious difference between plasma MMS levels from normal pregnant women and healthy nonpregnant women(p>0.05).Conclusions The changes of plasma MMS levels are believed to be association with pathogenesis of PIH and can be used as a biochemical marker for judging the progression of PIH.