| 骨桥蛋白在心力衰竭中的作用 |
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| 引用本文： | 胡文钰,汤安英,庞军,李玲.骨桥蛋白在心力衰竭中的作用[J].中国动脉硬化杂志,2020,28(10):917-920. |
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| 作者姓名： | 胡文钰 汤安英 庞军 李玲 |
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| 作者单位： | 贵州医科大学临床医学院临床医学专业,贵州省贵阳市 550000;贵州省人民医院心内科,贵州省贵阳市 550002 |
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| 基金项目： | 国家自然科学基金项目(81760071) |
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| 摘 要： | 近期相关研究提示,骨桥蛋白与心功能不全严重程度相关,其机制与介导细胞外基质表达,肾素-血管紧张素-醛固酮系统调控相关,有望作为心力衰竭患者临床评估的新的生物化学指标。本文就骨桥蛋白的结构、功能及其与心力衰竭相关的机制和意义进行综述。
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| 关 键 词： | 骨桥蛋白 心力衰竭 心室重塑 |
| 收稿时间： | 2019/10/14 0:00:00 |
| 修稿时间： | 2020/1/26 0:00:00 |
The role of osteopontin in heart failure |
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| HU Wenyu,TANG Anying,PANG Jun,LI Ling.The role of osteopontin in heart failure[J].Chinese Journal of Arteriosclerosis,2020,28(10):917-920. |
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| Authors: | HU Wenyu TANG Anying PANG Jun LI Ling |
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| Institution: | Clinical Medicine Major, School of Clinical Medicine, Guizhou Medical University, Guiyang, Guizhou 550000, China;Department of Cardiology, Guizhou Provincial People''s Hospital, Guiyang, Guizhou 550002, China |
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| Abstract: | Recent related studies suggest that osteopontin is related to the severity of cardiac insufficiency, and its mechanism is related to mediating the expression of extracellular matrix and the regulation of the renin angiotensin aldosterone system, which is expected to be a new biochemical indicator for clinical evaluation of patients with heart failure. This article reviews the structure and function of osteopontin and its mechanism and significance related to heart failure. |
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| Keywords: | osteopontin heart failure ventricular remodeling |
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