戒烟时间对稳定型心绞痛患者血浆高敏C反应蛋白及丙二醛浓度的影响

分析稳定型心绞痛患者戒烟时间对血浆高敏C反应蛋白及丙二醛浓度的影响。将 10 1例稳定型心绞痛患者根据吸烟情况分为吸烟组、不吸烟组及戒烟组 ,其中戒烟组又根据戒烟时间长短分为近期戒烟组和长期戒烟组。分别用颗粒增强超敏透射比浊法和硫代巴比妥酸法测定血浆高敏C反应蛋白及丙二醛浓度。结果发现 ,吸烟组血浆高敏C反应蛋白及丙二醛浓度较不吸烟组明显升高 (分别为 4 .82± 0 .37mg L比 1.74± 0 .31mg L和 1.0 8± 0 .31mmol L比 0 .86± 0 .2 0mmol L ,P均 <0 .0 1) ;长期戒烟组血浆高敏C反应蛋白浓度与近期戒烟组相比明显降低 (1.91± 0 .2 6mg L比 4 .6 6± 0 .2 4mg L ,P <0 .0 1) ;但丙二醛浓度在两组间无显著性差异 (0 .93± 0 .17mmol L比 0 .95± 0 .14mmol L ,P >0 .0 5 )。结果提示 ,吸烟对氧化应激及炎症介质均有影响 ,但对两者的作用时间长短可能不一致。

The Effect of Cease-Smoking Time on Plasma High Sensitive C-Reactive Protein and Malondialdehyde Levels of Stable Angina Pectoris Patients

Aim To study whether cease-smoking time takes effect on plasma high sensitive C-reactive protein (hsCRP) and malondialdehyde (MDA) levels of stable angina pectoris patients. Methods 101 subjects in hospital suffering from stable angina pectoris were investigated. The subjects were divided into 3 groups according to their smoking status: smokers, nonsmokers and former smokers who had stopped smoking. The last group were divided again into two subgroups according to different cease-smoking time: long time group and short time group. Levels of plasma MDA were determined by thibabituric acid method, while hsCRP by transmission turbidimetry method. Results Levels of plasma hsCRP and MDA were higher in smokers group than in nonsmokers group (4.82±0.37 mg/L to 1.74±0.31 mg/L,p<0.01; 1.08±0.31 mmol/L to 0.86±0.20 mmol/L,p<0.01); Levels of plasma hsCRP were lower in long time subgroup than in short time subgroup (1.91±0.26 mg/L to 4.66±0.24 mg/L,p<0.05), while levels of plasma MDA have no significant difference in the two subgroups (0.93±0.17 mmol/L to 0.95±0.14 mmol/L ,p>0.05). Conclusion Smoking takes effect on oxidative stress and inflammation to some extent but maybe it takes effect on them for a different time.