雷帕霉素抑制冠状动脉支架置入术后血管再内皮化相关机制进展

雷帕霉素是药物涂层支架最常用的载入药物,在抑制内膜增生的同时,也抑制了内皮细胞的功能,延迟损伤血管再内皮化,易引发支架内血栓形成。雷帕霉素抑制再内皮化的作用机制较为复杂,对其机制的研究是解决雷帕霉素不良作用的关键,也是近年来的研究热点。文章从内皮细胞功能、内皮细胞前体细胞、内皮细胞凋亡三个方面,就近年来对雷帕霉素延迟血管再内皮化作用机制的研究进展作一综述。

Role of rapamycin in delaying re-endothelialization after angioplasty

Rapamycin is the most widely employed drug in drug-eluting stents. It has markedly reduced the risk of restenosis after coronary angioplasty. However, it caused late stent thrombosis through impairing the function of endothelial cells and delaying the re-endothelialization. Role of rapamycin in delaying re-endothelialization is complicated. This paper reviews the progress in research of the mechanism of suppressing the proliferation and migration of endothelial cells, attenuating the function of endothelial progenitor cells and inducing apoptosis of endothelial cells.