| 脂肪功能紊乱参与心血管稳态失衡调控的研究进展 |
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| 引用本文： | 石晓东,阮承超.脂肪功能紊乱参与心血管稳态失衡调控的研究进展[J].中国动脉硬化杂志,2022,30(1):21-26. |
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| 作者姓名： | 石晓东 阮承超 |
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| 作者单位： | 复旦大学基础医学院生理与病理生理学系 |
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| 基金项目： | 国家自然科学基金项目(81922004、81870180)。 |
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| 摘 要： | 随着生活水平及生活方式的改变,以肥胖为特征的代谢性心血管疾病呈逐年增加的趋势。肥胖诱导脂肪组织的病理性扩充所导致的脂肪功能紊乱和脂肪因子内分泌失调参与心血管疾病发生发展的全过程。本文旨在综述不同类型的脂肪组织及新近发现的脂肪因子在生理或病理状态下,通过内分泌或旁分泌作用,参与心血管稳态维持或心血管疾病的调节,从而为肥胖相关的代谢性心血管疾病的防治提供新思路和新靶点。
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| 关 键 词： | 肥胖 脂肪组织 心血管疾病 内分泌 旁分泌 |
| 收稿时间： | 2021/8/4 0:00:00 |
| 修稿时间： | 2021/10/26 0:00:00 |
Research progress of adipose dysfunction involved in the regulation of cardiovascular homeostasis imbalance |
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| SHI Xiaodong,RUAN Chengchao.Research progress of adipose dysfunction involved in the regulation of cardiovascular homeostasis imbalance[J].Chinese Journal of Arteriosclerosis,2022,30(1):21-26. |
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| Authors: | SHI Xiaodong RUAN Chengchao |
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| Institution: | (Department of Physiology and Pathophysiology,College of Basic Medicine,Fudan University,Shanghai 200032,China) |
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| Abstract: | With the changes of living standard and lifestyle,metabolic cardiovascular diseases characterized by obesity are increasing by years.The disorder of adipose function and adipocytokines,because of adipose tissue’s pathological expansion induced by obesity,participates in the whole process of the occurrence and development of cardiovascular disease.This article reviews different types of adipose tissue involve in maintenance of cardiovascular homeostasis or regulation of cardiovascular disease by endocrine or paracrine effects under physiological or pathological conditions.Therefore,it provides new ideas and new targets for the precise treatment of obesity-related metabolic cardiovascular diseases. |
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| Keywords: | obesity adipose tissue cardiovascular disease endocrine paracrine |
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