高密度脂蛋白逆转运胆固醇的分子生物学基础

高密度脂蛋白(HDL)能够将胆固醇从泡沫细胞中转运到肝脏,代谢转化为胆汁排出体外,进而产生抗动脉粥样硬化作用,称之为HDL的胆固醇逆转运(RCT)。因此,如何提高HDL浓度并促进HDL的功能,充分发挥其抗动脉粥样硬化的功能,成为近年来研究的热点。但研究显示单纯升高HDLC并未发现有明显的临床效果,揭示了HDL功能的复杂性。因此有必要进行系统的回顾HDL的分子结构、合成、代谢等,重新认识其RCT功能的分子生物学基础,为进一步研究HDL的RCT功能提供理论支撑。

Molecular biological basis of reverse cholesterol transport by high density lipoprotein

High density lipoprotein (HDL) can transfer cholesterol from foam cells to the liver and metabolize it into bile and excreted into intestinal tract, finally exhaust out of body, then it produces an anti-atherosclerosis effect, which is called HDL''s reverse cholesterol transport (RCT). Therefore, how to increase the concentration of HDL and promote the function of HDL to give full play to its anti-atherosclerosis function are becoming a research hotspot in recent years. However, studies have shown that simple elevation of HDLC level has no significant clinical effect, revealing the complexity of HDL function. Therefore, it is necessary to systematically review the molecular structure, synthesis and metabolism of HDL, and re-recognize the molecular biological basis of its RCT function, so as to provide theoretical support for further research on the RCT function of HDL.