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Clinical characterization of men with long QT syndrome and torsades de pointes associated with hypogonadism: A review and pharmacovigilance study
Institution:1. Inserm, UNICO-GRECO Cardio-Oncology Programme, Department of Pharmacology, CIC-1421, Pharmacovigilance Unit, Pitié-Salpêtrière Hospital, Sorbonne Université, AP–HP, 75013 Paris, France;2. Pharmacology and Cardio-Oncology Program, Departments of Medicine, Vanderbilt University Medical Center, 37232 Nashville, TN, USA;3. Inserm, ICAN, Rythmology Unit, Department of Cardiology, Pitié-Salpêtrière Hospital, Sorbonne Université, AP–HP, 75013 Paris, France;4. Department of Endocrinology and Reproductive Medicine, IE3M, centre de référence des maladies endocriniennes rares de la croissance et centre des pathologies gynécologiques rares, ICAN, Pitié-Salpêtrière Hospital, AP–HP, 75013 Paris, France
Abstract:
Keywords:Torsades de pointes  Hypogonadism  Long QT syndrome  Testosterone  Androgen deprivation therapy  Torsade-de-Pointes  Hypogonadisme  Syndrome du QT Long  Testostérone  Anti-androgène  ADR"}  {"#name":"keyword"  "$":{"id":"kw0060"}  "$$":[{"#name":"text"  "_":"Adverse Drug Reaction Report  ADT"}  {"#name":"keyword"  "$":{"id":"kw0070"}  "$$":[{"#name":"text"  "_":"Androgen Deprivation Therapy  aLQTS"}  {"#name":"keyword"  "$":{"id":"kw0080"}  "$$":[{"#name":"text"  "_":"acquired Long QT Syndrome  BNPV"}  {"#name":"keyword"  "$":{"id":"kw0090"}  "$$":[{"#name":"text"  "_":"Base Nationale de Pharmacovigilance (French pharmacovigilance database)  ICD"}  {"#name":"keyword"  "$":{"id":"kw0100"}  "$$":[{"#name":"text"  "_":"Implantable Cardioverter-Defibrillator  LQTS"}  {"#name":"keyword"  "$":{"id":"kw0110"}  "$$":[{"#name":"text"  "_":"Long QT Syndrome  PVR"}  {"#name":"keyword"  "$":{"id":"kw0120"}  "$$":[{"#name":"text"  "_":"Pharmacovigilance Case Report  QTc"}  {"#name":"keyword"  "$":{"id":"kw0130"}  "$$":[{"#name":"text"  "_":"QT interval corrected for heart rate  TdP"}  {"#name":"keyword"  "$":{"id":"kw0140"}  "$$":[{"#name":"text"  "_":"Torsades de Pointes
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