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幽门螺杆菌致病机制及益生菌防治作用的研究进展
引用本文:陈云华,汪春莲,谢云. 幽门螺杆菌致病机制及益生菌防治作用的研究进展[J]. 世界华人消化杂志, 2007, 15(25): 2690-2697
作者姓名:陈云华  汪春莲  谢云
作者单位:中南大学湘雅二医院,湖南省长沙市,410005;长沙市卫生学校,湖南省长沙市,410100
摘    要:幽门螺杆菌(H pylori)己被确认与慢性胃炎、消化性溃疡、胃黏膜相关淋巴样组织淋巴瘤和胃癌密切相关,目前多种抗生素联合治疗仍是抗H pylori感染的主要方法,但是由于细菌抗药性的出现、以及长期不合理应用抗生素可引起不良反应,因此近年提出了抗H pylori感染一些新方法,其中益生菌在提高H pylori根除率及减少药物不良反应方面尤显优势,而且还具有维持胃肠道微生态的稳定、减轻黏膜炎症反应等多种作用,本文就H pylori的致病机制及益生菌治疗H pylori感染的研究进展作一综述.

关 键 词:幽门螺杆菌  致病机制  益生菌  治疗
收稿时间:2007-05-27
修稿时间:2007-08-25

Progress of research into the pathogenic mechanism of Helicobacter pylori and the preventive role of probiotics in H pylori infection
Yun-Hua Chen,Chun-Lian Wang,Yun Xie. Progress of research into the pathogenic mechanism of Helicobacter pylori and the preventive role of probiotics in H pylori infection[J]. World Chinese Journal of Digestology, 2007, 15(25): 2690-2697
Authors:Yun-Hua Chen  Chun-Lian Wang  Yun Xie
Abstract:Helicobacter pylori,a highly prevalent pathogen, is a major cause of chronic gastritis and peptic ulcer and a risk factor for gastric malignancies or gastric mucosa-associated lymphoid tissue (MALT) lymphoma.Antibiotic-based H pylori eradication is currently regarded as the gold standard.However,it is expensive and causes side effects,and the rapid development of antibiotic-resistant strains may soon prevent their large-scale use.Recently,many new therapeutic strategies are being studied to improve the H pylori eradication rate.The use of probiotics in the field of H pylori infection has been proposed for improving eradication, tolerability and compliance with multiple antibiotic regimens.In addition,probiotics have a possible role in the stabilization of the gastric barrier function and reducing mucosal inflammation.In this article,we review the development of research on the molecular mechanism of H pylori infection and the mechanisms of action and clinical significance of probiotics.
Keywords:Helicobacter pylori  Pathogenic mechanism  Probiotics
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