幽门螺杆菌致病机制及益生菌防治作用的研究进展

幽门螺杆菌(H pylori)己被确认与慢性胃炎、消化性溃疡、胃黏膜相关淋巴样组织淋巴瘤和胃癌密切相关,目前多种抗生素联合治疗仍是抗H pylori感染的主要方法,但是由于细菌抗药性的出现、以及长期不合理应用抗生素可引起不良反应,因此近年提出了抗H pylori感染一些新方法,其中益生菌在提高H pylori根除率及减少药物不良反应方面尤显优势,而且还具有维持胃肠道微生态的稳定、减轻黏膜炎症反应等多种作用,本文就H pylori的致病机制及益生菌治疗H pylori感染的研究进展作一综述.

Progress of research into the pathogenic mechanism of Helicobacter pylori and the preventive role of probiotics in H pylori infection

Helicobacter pylori,a highly prevalent pathogen, is a major cause of chronic gastritis and peptic ulcer and a risk factor for gastric malignancies or gastric mucosa-associated lymphoid tissue (MALT) lymphoma.Antibiotic-based H pylori eradication is currently regarded as the gold standard.However,it is expensive and causes side effects,and the rapid development of antibiotic-resistant strains may soon prevent their large-scale use.Recently,many new therapeutic strategies are being studied to improve the H pylori eradication rate.The use of probiotics in the field of H pylori infection has been proposed for improving eradication, tolerability and compliance with multiple antibiotic regimens.In addition,probiotics have a possible role in the stabilization of the gastric barrier function and reducing mucosal inflammation.In this article,we review the development of research on the molecular mechanism of H pylori infection and the mechanisms of action and clinical significance of probiotics.