| 丙型肝炎病毒非结构蛋白与宿主细胞蛋白相互作用的研究进展 |
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| 引用本文： | 张丹,冯国和.丙型肝炎病毒非结构蛋白与宿主细胞蛋白相互作用的研究进展[J].世界华人消化杂志,2011(2):161-169. |
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| 作者姓名： | 张丹 冯国和 |
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| 作者单位： | 中国医科大学附属盛京医院感染科; |
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| 摘 要： | 丙型肝炎病毒(hepatitis C virus,HCV)是继乙型肝炎病毒(hepatitis B virus,HBV)之后另一个导致慢性肝炎、肝硬化和肝癌的常见原因.目前HCV致病及致癌机制仍不清楚,也缺乏针对HCV有效的治疗方法及疫苗预防.肝炎病毒蛋白与受染细胞蛋白之间相互作用是肝炎发病机制研究的热点内容.近年研究...
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| 关 键 词： | 丙型肝炎病毒 非结构蛋白 蛋白质相互作用 致癌作用 干扰素抵抗 |
Advances in research of interaction between hepatitis C virus nonstructural proteins and host proteins |
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| Dan Zhang,Guo-He Feng.Advances in research of interaction between hepatitis C virus nonstructural proteins and host proteins[J].World Chinese Journal of Digestology,2011(2):161-169. |
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| Authors: | Dan Zhang Guo-He Feng |
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| Institution: | Dan Zhang,Guo-He Feng,Department of Infectious Diseases,Shengjing Hospital of China Medical University,Shenyang 110004,Liaoning Province,China |
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| Abstract: | Hepatitis C virus (HCV) is another common cause of chronic hepatitis,liver cirrhosis,and hepatocellular carcinoma after hepatitis B virus (HBV).Up to now,the mechanisms by which HCV promotes persistent infection and cancer remain unclear,and there are neither effective drugs nor vaccines against HCV available.Interaction between virus proteins and host proteins is a hot topic in research of the pathogenesis of viral hepatitis.Recent research shows that interaction between HCV nonstructural proteins and host... |
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| Keywords: | Hepatitis C virus Nonstructural protein Protein-protein interaction Carcinogenesis Interferon resistance |
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