Toll样受体及其基因多态性与感染性疾病关系的研究进展

Toll样受体是近年来发现的跨膜信号传递受体,他作为一种重要的模式识别受体(PRRs)在先天免疫中通过对病原体相关的分子模式(PAMPs)的识别发挥作用,通过刺激信号的级联反应诱导炎症因子和细胞因子产生,在抗感染中起重要作用.基因多态性影响机体对疾病的遗传易感性,TLRs的位点多态性与炎性应答损伤和感染性疾病的遗传易感性相关.目前多数研究表明TLR4的Asp299Gly和Thr399Ile,TLR2的Arg753Gln和Arg667Trp多态性与感染性疾病的发生相关,其他TLRs的基因多态性也有研究.本文就TLRs家族的功能及其基因多态性与感染性疾病的关系作一综述.

Advancement of the relationship between gene polymorphisms of Toil-like receptors and infectious diseases

Toll-like receptors(TLRs)were identified as transmembrane signal transduction proteins in recent years.As a group of pattern recognition receptors(PRRs),TLRs play important roles in the innate immunity by recognizing pathogen- associated molecular patterns(PAMPs).PAMPs trigger TLR signaling cascades,leading to the release of proinflammatory cytokines,and play critical roles in infectious diseases.Ge- netic polymorphisms affect the susceptibility of individuals to infectious diseases,and single nucleotide polymorphisms of TLR genes are associated with the inflammatory responses and susceptibility to infectious diseases.Most studies have indicated that the Asp299Gly and Thr399Ile of TLR4 as well as the Arg753Gln and Arg667Trp of TLR2 had close correlations with the pathogenesis of infectious diseases.Other genetic polymorphisms of TLRs have also been reported.In this review,we summarized and discussed the function of TLR family and the relationship between genetic polymorphisms of TLRs and infectious diseases.