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鼠移植性肝癌内注射乙酸的治疗实验
引用本文:赵永锋,闻勤生,贾战生.鼠移植性肝癌内注射乙酸的治疗实验[J].世界华人消化杂志,1999,0(1):1.
作者姓名:赵永锋  闻勤生  贾战生
作者单位:第四军医大学唐都医院,武警技术学院医院内科
摘    要:目的观察300mL/L乙酸局部注射治疗裸鼠移植瘤的效果,并探讨其作用机制.方法应用人肝癌(hHCC)细胞悬液接种于Balb/cnu/nu裸鼠皮下建立移植瘤模型共12只,分为3组,乙酸组5只注射300mL/L乙酸015mL,乙醇组5只注射无水乙醇015mL,盐水组2只注射生理盐水015mL,2次/wk,共4次.观察移植瘤生长情况.结果乙酸组移植瘤全部结痂、脱落,而乙醇组除一只裸鼠移植瘤结痂、脱落外其余均明显缩小(P<005),盐水组移植瘤呈结节样进行性生长.病理学检查:乙酸组可见纤维组织未见肝癌细胞,乙醇组除大片组织坏死外可见散在的肝癌细胞团,盐水组肝癌细胞生长良好.结论300mL/L乙酸较无水乙醇能产生更广泛的组织坏死,可以代替无水乙醇局部注射治疗hHCC.

关 键 词:肝肿瘤/治疗  乙酸  肿瘤移植  疾病模型.动物
修稿时间:1998-07-06

Local acetic acid injection in the treatment of transplanted tumor in mice
ZHAO Yong Feng ,WEN Qin Sheng and JIA Zhan Sheng.Local acetic acid injection in the treatment of transplanted tumor in mice[J].World Chinese Journal of Digestology,1999,0(1):1.
Authors:ZHAO Yong Feng    WEN Qin Sheng and JIA Zhan Sheng
Institution:ZHAO Yong Feng 1,3,WEN Qin Sheng 1 and JIA Zhan Sheng 2 1Department of Gastroenterology,2Department of Infectious Diseases,Tangdu Hospital,Fourth Military Medical University,Xi'an 710038,Shaanxi Province,China 3Depart
Abstract:AIM To study the effect of 300mL/L acetic acid on the transplanted hepatic tumor in nude mice and its mechanism of action. METHODS Twelve nude Balb/c (nu/nu) mice were transplanted with human hepatocellular carcinoma line (hHCC) hypodermically, then divided into three groups. Five mice were injected locally with 300mL/L acetic acid, 5 with ethanol and 2 with saline, 0 15mL twice weekly for 4 times, respectively. RESULTS All 5 mice of acetic acid group showed the scabbing and scaling of transplanted tumors while only 1 in the ethanol group presented the same ( P <0 05), but none of saline controls after therapy. Histopathologically, acetic acid group revealed local fibrosis without tumor cells and ethanol group tissue necrosis with scattering tumor cells but control only progressive growth of nodular carcinoma. CONCLUSION Three hundred mL/L acetic acid destroys effectively transplanted tumor in the nude mice and may replace ethanol as local injection to control human liver carcinoma.
Keywords:liver neoplasms/therapy  acetic acid  neoplasm transplantation  disease models  animal  nude mice  
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