| 组织芯片技术检测食管癌前病变相关预警标志物 |
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| 引用本文： | 滕梁红,吕宁,赵晓航,薛丽燕,刘芳,林冬梅,王卉心,何祖根,谢永强,刘秀云.组织芯片技术检测食管癌前病变相关预警标志物[J].世界华人消化杂志,2005,13(1):6-9. |
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| 作者姓名： | 滕梁红 吕宁 赵晓航 薛丽燕 刘芳 林冬梅 王卉心 何祖根 谢永强 刘秀云 |
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| 作者单位： | 中国协和医科大学,中国医学科学院,肿瘤医院肿瘤研究所病理科,北京市,100021;中国协和医科大学,中国医学科学院,肿瘤医院 |
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| 基金项目： | 国家自然科学基金,NO．30271460,No．30225045,No.30171049
国家高技术(863)研究发展计划,No．2004AA227060 |
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| 摘 要： |
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| 关 键 词： | annexinⅠ 突变型p53 Ki-67 Grp94 食管癌 |
| 收稿时间： | 2005-09-03 |
| 修稿时间： | 2004年10月18 |
Detection of tumor-associated biomarkers in precancerous lesions of esophagus |
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| Liang-Hong Teng,Ning Lv,Xiao-Hang Zhao,Li-Yan Xue,Fang Liu,Dong-Mei Lin,Hui-Xin Wang,Zu-Gen He,Yong-Qiang Xie,Xiu-Yun Liu.Detection of tumor-associated biomarkers in precancerous lesions of esophagus[J].World Chinese Journal of Digestology,2005,13(1):6-9. |
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| Authors: | Liang-Hong Teng Ning Lv Xiao-Hang Zhao Li-Yan Xue Fang Liu Dong-Mei Lin Hui-Xin Wang Zu-Gen He Yong-Qiang Xie Xiu-Yun Liu |
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| Institution: | Liang-Hong Teng,Ning Lv,Li-Yan Xue,Dong-Mei Lin,Zu-Gen He,Yong-Qiang Xie,Xiu-Yun Liu,Department of Pathology,Cancer Institute and Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100021,China Xiao-Hang Zhao,Fang Liu,Hui-Xin Wang,National Laboratory of Molecular Oncology,Cancer Institute and Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100021,China |
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| Abstract: | AIM: To investigate the expressions of annexin I, Grp94, p53, Ki-67 in esophageal squamous cell carcinoma (ESCC) and precancerous lesion, in order to provide valuable clues for early diagnosis. METHODS: Seventy-two specimens were collected, including dysplasia, in situ carcinoma, early ESCC, ESCC and lymph metastatic carcinoma. The expression of annexin I, Grp94, mutant p53 and ki-67 were detected using immunohistochemical staining (IHC). RESULTS: Compared with the normal esophageal epithelia, the expressions of annexin I, Grp94, mutant p53 and ki-67 were abnormal in precancerous lesions. Loss of annexin I (68.3%), positive expression of p53 (67.6%) and ki-67 (71.1%) were observed in low grade lesions (P<0.01), and Grp94 expression was increased significantly (62.0%) in early invasive cancer (P<0.01). CONCLUSION: Annexin I, mutant p53 and ki-67 may be the biomarkers of early ESCC, and Grp94 may be an important biomarker of progressive ESCC. |
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| Keywords: | Annexin I Mutant p53 ki-67 Grp94 ESCC |
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