| 血小板衍化内皮细胞生长因子在胰腺癌组织中的表达及其临床意义 |
| |
| 引用本文： | 唐光华,倪润洲,肖明兵,江枫,陈健华,黄华.血小板衍化内皮细胞生长因子在胰腺癌组织中的表达及其临床意义[J].世界华人消化杂志,2010,18(2). |
| |
| 作者姓名： | 唐光华 倪润洲 肖明兵 江枫 陈健华 黄华 |
| |
| 作者单位： | 南通大学附属医院消化内科,江苏省南通市,226001 |
| |
| 基金项目： | 江苏省"六大人才高峰"项目，南通市社会发展基金 |
| |
| 摘 要： | 目的:观察血小板衍化内皮细胞生长因子(PD-ECGF)在胰腺癌组织中的表达,探讨其临床意义.方法:利用Elivison免疫组织化学法检测36例手术切除的胰腺癌及21例癌旁正常胰腺组织,以及胃癌、食管癌、肝癌、结肠癌、肺癌及乳腺癌组织各10例中PD-ECGF的表达.分析PD-ECGF与胰腺癌大小、分化程度及淋巴结转移的相关性.结果:PD-ECGF在胰腺癌组织中的表达阳性率显著高于在癌旁正常胰腺组织(88.9% vs 28.6%,P<0.01).PD-ECGF在结肠癌、肝癌、乳腺癌、食管癌、胃癌及肺癌组织中的表达阳性率为60%、70%、80%、90%、90%及80%.Ⅱ-Ⅳ期胰腺癌组织中PD-ECGF的表达阳性率显著高于Ⅰ期胰腺癌组织(100% vs 75%,P<0.05).结论:PD-ECGF为一种非特异性的肿瘤相关因子,其可能与胰腺癌的病程进展有关.
|
| 关 键 词： | 血小板衍化内皮细胞生长因子 胰腺癌 胰腺癌标志物 |
Clinical significance of PD-ECGF expression in human pancreatic carcinoma |
| |
| Guang-Hua Tang,Run-Zhou Ni,Ming-Bing Xiao,Feng Jiang,Jian-Hua Chen,Hua Huang.Clinical significance of PD-ECGF expression in human pancreatic carcinoma[J].World Chinese Journal of Digestology,2010,18(2). |
| |
| Authors: | Guang-Hua Tang Run-Zhou Ni Ming-Bing Xiao Feng Jiang Jian-Hua Chen Hua Huang |
| |
| Institution: | Guang-Hua Tang,Run-Zhou Ni,Ming-Bing Xiao,Feng Jiang,Jian-Hua Chen,Hua Huang,Department of Gastroenterology,the Affiliated Hospital of Nantong University Nantong 226001,Jiangsu Province,China |
| |
| Abstract: | AIM:To investigate the expression of plateletderived endothelial cell growth factor (PDECGF) in human pancreatic carcinoma and evaluate its clinical significance.METHODS:Immunohistochemistry was used to detect the expression of PD-ECGF in 36 paraffinembedded pancreatic carcinoma specimens,21 tumor-adjacent normal tissue specimens,and 60 cancerous specimens derived from other tissues (stomach,colon,esophagus,liver,lung and breast;10 specimens each).The expression of PD-ECGF in different tissues was compared.... |
| |
| Keywords: | PD-ECGF Pancreatic carcinoma Marker for pancreatic carcinoma |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
