鼠李糖乳杆菌治疗肠易激综合征机制新进展

肠易激综合征(irritable bowel syndrome,IBS)是临床上常见的功能性胃肠病,其会影响患者的生活质量.因此探寻IBS的有效治疗方法具有重要意义.益生菌可改善IBS患者的症状并提高其生活质量,其中备受关注的是鼠李糖乳杆菌(Lactobacillus rhamnosus GG,LGG).LGG是目前被研究最多的益生菌之一.LGG已经在临床上被用来治疗IBS,且近年来LGG治疗IBS机制不断有新的进展.LGG可通过调节肠道菌群失调、保护肠道屏障功能、抗炎、调节肠道免疫、改善内脏高敏感和抑菌来发挥作用从而改善IBS症状.本文就LGG治疗IBS的可能机制作一综述.

Mechanism of Lactobacillus rhamnosus in treatment of irritable bowel syndrome

Irritable bowel syndrome(IBS)is a clinically common functional gastrointestinal disease,which affects the quality of life of patients.Therefore,it is of great significance to explore effective treatment methods for IBS.Probiotics can improve the symptoms of IBS patients and their quality of life.Lactobacillus rhamnosus is one of the most studied probiotics and has attracted much attention..Lactobacillus rhamnosus has been used to treat IBS,and much progress has been made in recent years.Lactobacillus rhamnosus can improve the symptoms of IBS by regulating the imbalance of the intestinal flora,protecting the intestinal barrier function,exerting antiinflammatory activity,regulating the intestinal immunity,improving visceral hypersensitivity,and inhibiting bacteria.This review aims to elucidate the possible mechanism of Lactobacillus rhamnosus in the treatment of IBS.