促红细胞生成素及血红蛋白与老年慢性心力衰竭患者的相关性

目的探讨促红细胞生成素(EPO)和血红蛋白(Hb)与慢性心力衰竭(CHF)的相关性。方法选择老年CHF患者1 69例,根据本次住院确诊的心功能(NYHA)Ⅰ、Ⅱ、Ⅲ和Ⅳ级依次分为1组33例、2组34例、3组59例和4组4 3例。对4组患者Hb、EPO及是否死亡进行logistic回归分析。结果与1组比较,2、3和4组lg EPO水平明显上升,Hb水平明显下降(P<0.01);4组患者lg EPO和Hb水平两两比较,差异均有统计学意义(P<0.01)。Hb、EPO及肌酐(OR=0.978,35.820,1.013,P<0.01)均是影响老年CHF患者住院死亡的危险因素。结论 EPO随患者CHF程度的加重而升高,Hb值则降低。Hb、EPO及肌酐均为影响CHF患者住院死亡的危险因素。

Relationship between EPO, Hb and chronic heart failure in old patients

Objective To study the relationship between erythropoietin(EPO),hemoglobin(Hb) and chronic heart failure(CHF).Methods According to New York Heart Association(NYHA) heart function class,169 patients with CHF history were divided into four groups:gradeⅠ(group 1,33 cases),gradeⅡ(group 2,34 cases),gradeⅢ(group 3,59 cases) and gradeⅣ(group 4,43 cases).One-way ANOV and logistic regression analysis were used to assess whether or not EPO, Hb and Cr were the risk factors for hospital mortality.Results Compared with group 1,lg plasma EPO of groups 2,3,4 significantly increased and Hb significantly decreased(P<0.01).There were significant differences in Hb and lg plasma EPO among the four groups(P<0.01).Logistic analysis showed that hemoglobin(OR = 0.978,P = 0.000),lg plasma EPO(OR = 35.820, P = 0.000) and Cr were risk factors for hospital mortality in old CHF patients.Conclusion The level of Hb was significantly decreased with the severity of heart failure.The level of EPO was significantly increased with severity of heart failure.Hemoglobin,EPO levels and Cr were risk factors for hospital mortality in CHF patients.