进展性缺血性脑卒中患者血清铁蛋白测定的临床意义

目的探讨进展性缺血性脑卒中(progressive ischemic stroke,PIS)患者血清铁蛋白测定的临床意义。方法选择河北联合大学附属医院神经内科住院治疗的急性前循环缺血性脑卒中患者133例,根据病情变化分为PIS组50例,非PIS组83例。采用放射免疫法测定血清铁蛋白浓度。结果与非PIS组比较,PIS组患者第1、3、7天铁蛋白水平明显升高,差异有统计学意义(P<0.01)。PIS组患者铁蛋白水平与第1天比较,第3天达高峰,第7天下降且低于第1天,差异有统计学意义(P<0.01)。随着铁蛋白水平升高,缺血性脑卒中进展的危险度呈上升趋势(χ2=20.63,P<0.01)。结论铁蛋白水平升高是缺血性脑卒中进展的重要危险因素。随着缺血性脑卒中患者早期铁蛋白水平升高,病情进展的危险性增加。

Measurement of serum ferritin level in patients with progressive ischemic stroke and its clinical significance

Objective To study the measurement of serum ferritin level in patients with progressive ischemic stroke(PIS) and its clinical significance.Methods One hundred and thirty-three PIS patients,admitted to Department of Neurology,Affiliated Hospital of Hebei Union University,were divided into PIS group(n=50) and non-PIS group(n=83).Their serum ferritin(SF) levels were measured by radioimmunoassay.Results The SF level was significantly higher in PIS group than in non-PIS group on days 1,3 and 7(P<0.01) and significantly lower in PIS group on day 7 than on day 1(P<0.01).The risk of PIS tended to increase with the elevating SF level(χ2=20.63,P<0.01).Conclusion Elevated SF level is an important risk factor for PIS.The risk of PIS increases with the early elevated SF level in ischemic stroke patients.