急性脑梗死患者巨噬细胞趋化因子配体16与颈动脉粥样硬化斑块不稳定性的关系

目的探讨急性脑梗死患者血清可溶性巨噬细胞趋化因子配体16(CXCL16)水平与颈动脉粥样硬化斑块不稳定性及预后的关系。方法选择40例急性颈内动脉系统脑梗死患者为病例组,其中稳定斑块9例和不稳定斑块31例,同期健康体检者40例为对照组,应用颈动脉超声评估颈动脉粥样硬化斑块的形态学特点,ELISA法检测2组不同时间血清CXCL16水平。结果病例组发病72h血清CXCL16水平显著高于对照组(5.00±1.77)ng/L vs(4.28±0.74)ng/L,P<0.05];不稳定斑块患者发病72h及1周时血清CXCL16水平显著高于稳定斑块患者(P<0.01);复发患者发病72h及1周时血清CXCL16水平明显高于未复发患者(6.24±1.26)ng/L vs(4.68±1.92)ng/L,(5.55±1.23)ng/L vs(4.25±1.51)ng/L,P<0.05]。结论血清CXCL16水平在脑梗死急性期升高,与动脉粥样硬化斑块的稳定性密切相关,可能提示预后不良。

Relation between CXCL16 and instable carotid atherosclerotic plaques in patients with acute ischemic cerebral stroke

Objective To study the relation of serum CXCL16 level with instable carotid atherosclerotic plaques in patients with acute ischemic cerebral stroke and their prognosis.Methods Forty acute cerebral stroke patients(9 with stable carotid atherosclerotic plaques and 31 with instable carotid atherosclerotic plaques) served as a patients group and 40 subjects undergoing health check served as a control group.The morphological features of their carotid atherosclerotic plaques were assessed by carotid ultrasonography and their serum CXCL16 levels at different time points were measured by ELISA.Results The serum CXCL16 level was significantly higher in patients group than in control group at 72 h after onset of the disease(5.00±1.77 ng/L vs 4.28±0.74 ng/L,P<0.05),in patients with instable carotid atherosclerotic plaques than in those with stable carotid atherosclerotic plaques(P<0.01) and in patients with relapse than in those without relapse at 72 h and 1 week after onset of the disease(6.24±1.26 ng/L vs 4.68±1.92 ng/L,5.55±1.23 ng/L vs 4.25±1.51 ng/L,P<0.05).Conclusion The serum CXCL16 level increases in patients with acute cerebral stroke,which is closely related with the instable carotid atherosclerotic plaques and suggests a poor prognosis of the patients.