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非糖尿病代谢综合征与颈动脉粥样硬化的研究
引用本文:邹密,蒋利,钟健,倪银星,徐兴森,闫振成,陈静,赵志钢,祝之明.非糖尿病代谢综合征与颈动脉粥样硬化的研究[J].中华老年心脑血管病杂志,2007,9(5):323-325.
作者姓名:邹密  蒋利  钟健  倪银星  徐兴森  闫振成  陈静  赵志钢  祝之明
作者单位:第三军医大学全军高血压代谢病中心,大坪医院野战外科研究所高血压内分泌科重庆市高血压研究所,重庆,400042
基金项目:国家重点基础研究发展计划(973计划)
摘    要:目的研究非糖尿病的代谢综合征(MS)对颈动脉粥样硬化的影响,为临床动脉粥样硬化性心血管疾病的防治提供依据。方法依据国际糖尿病联盟MS诊断标准将446例非糖尿病患者分为非MS组(298例)及MS组(148例),应用彩色多普勒超声检测颈动脉血管结构及功能,分析两组间颈动脉损害情况的差异。结果MS组腰围、甘油三酯、高密度脂蛋白胆固醇、稳态模型评估法的胰岛素抵抗指数、糖化血红蛋白(HbA1c)显著高于非MS组(P<0.01,P<0.05);非MS组动脉斑块发生率仍较高,其颈动脉内膜中层厚度(IMT)和斑块指数与MS组相似,而MS组虽不伴糖尿病,但其HbA1c较非MS组高。直线相关分析显示,IMT与总胆固醇(TC)、年龄、HbA1c、收缩压呈正相关(P<0.01,P<0.05);逐步回归分析显示IMT与TC、年龄、HbA1c相关。结论MS在不合并糖尿病时,其颈动脉损害仍较明显,HbA1c明显升高,可能预示MS易发展为糖尿病和较严重的动脉粥样硬化性心血管疾病。

关 键 词:颈动脉疾病  代谢疾病  血红蛋白类  糖尿病血管病变  危险因素
文章编号:1009-0126(2007)05-0323-03
修稿时间:2006-12-25

Study of carotid atherosclerosis in patients with non-diabetic metabolic syndrome
ZOU Mi, JIANG Li, ZHONG Jian, et al.Study of carotid atherosclerosis in patients with non-diabetic metabolic syndrome[J].Chinese Journal of Geriatric Cardiovascular and Cerebrovascular Diseases,2007,9(5):323-325.
Authors:ZOU Mi  JIANG Li  ZHONG Jian  
Institution:Department of Hypertension and Endocrinology, Daping Hospital, Third Military Medical University, Chongqing 400042, China
Abstract:Objective To investigate the status of carotid artery atherosclerosis in patients with non-diabetic metabolic syndrome(MS) for providing clinical evidence to prevent and treat atherosclerotic cardiovascular diseases(ASCVD).Methods 446 non-diabetic patients were divided into two groups: without MS group(298 cases) and with MS group(148 cases).The structure and function of carotid artery were examined by color Doppler.Results Compared with patients without MS,the WC,triglyceride(TG),high-density lipoprotein cholesterol(HDLC),homeostasis model assessment of insulin resistance(HOMA-IR),and glycosylated hemoglobin in patients with MS were higher(P<0.05 or P<0.01).No significant difference in the incidence rate of carotid plaque was observed between two groups.The carotid intima-media thickness(IMT) and plaque index were similar in two groups.There were positive correlations between IMT and total cholesterol(TC),age,glycosylated hemoglobin(HbA1c),systolic blood pressure(SBP).By stepwise regression analysis,TC,age,HbA1c were independently correlated with IMT.Conclusion The damage of carotid artery in patients with non-diabetic MS was still very serious.Compared with non-MS,HbA1c was significantly higher in patients with MS,which may indicate that MS is apt to be complicated by diabetes and severe ASCVD.
Keywords:carotid artery diseases  metabolic diseases  hemoglobins  diabetic angiopathies  risk faetors
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