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1998年上海地区细菌耐药性监测
作者姓名:Wang F  Wu S  Zhu D
作者单位:上海医科大学华山医院!上海抗生素研究所200040
摘    要:目的 对上海医院中临床分离菌进行耐药性监测,指导临床合理用药。方法 用Kirby-Bauer法进行药敏试验,根据1997年NCCLS判断结果。结果 临床分离菌中革兰阳性球菌有增多趋势。金黄色葡萄球菌(SA)和凝固酶阴性葡萄球菌(CNS)中耐甲氧西林SEA(MRSA)和耐甲氧西林CNS(MRCNS)分别约占70.7%和54.9%但对万古霉素均敏感,肠球菌属中万古霉素耐药株约5%,克雷白菌属,沙雷菌属

关 键 词:抗药性  微生物  敏感性试验  耐药性  监测

Surveillance of bacterial resistance in Shanghai in 1998
Wang F,Wu S,Zhu D.Surveillance of bacterial resistance in Shanghai in 1998[J].Chinese Journal of Internal Medicine,1999,38(11):729-732.
Authors:Wang F  Wu S  Zhu D
Institution:Institute of Antibiotics, Huashan Hospital, Shanghai Medical University, Shanghai 200040.
Abstract:Objective To investigate the resistance of clinical bacterial isolates as a reference for rational use of antibiotics. Methods Using Kirby Bauer method for bacterial susceptibility testing and NCCLS 1997 as assessment criteria. Results The number of Gram positive organisms was increasing in clinical isolates. Among the Staphalcocci aureus (SA) and coagulase negative Saphylococci (CNS), methicillin resistant SA (MRSA) and methicillin resistant CNS (MRCNS) accounted for 70.7% and 54.9% respectively, but no vancomycin resistant strain was found. Vancomycin resistant Enterococci was about 5%. Resistant rates of Klebsiella spp , Serratia spp , Enterobacter spp and Acinetobacter spp against third generation cephalosporins and fluoroquinolones increased markedly. The resistant rates of most Enterobacteriaceae species against imipenem were increasing gradually, while the resistant rates of Pseadomonas aeruginosa against ceftazidime, cefoperazone and imipenem were significantly higher as compared with the data in 1994. Conclusion The urgent need of restricting the misuse of antibiotics.
Keywords:Drug resistance  microbial    Microbial susceptibility testing
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