上海地区中国人血脂紊乱类型与胰岛素抵抗

目的：探讨上海地区中国人脂代谢紊乱的类型与胰岛素抵抗的关系。方法：830例年龄≥40岁（男300例，女530例）正常人和血脂紊乱者，后者分为7个亚组，包括单纯低高密度脂蛋白（HDL）组（亚组Ⅰ）、单纯高甘油三酯（TG）组（亚组Ⅱ）、单纯高胆固醇（TC）或高低密度脂蛋白（LDL）组（亚组Ⅲ）、低HDL合并高TG组（亚组Ⅳ）、低HDL合并高TC或高LDL组（亚组Ⅴ）、高TG合并高TC或高LDL组（亚组Ⅵ）、低HDL合并高TG及高TC或高LDL组（亚组Ⅶ），用稳态模式评估法（HOMA）评价胰岛素抵抗（IR）。结果：校正年龄、性别、体重指数等因素后，伴有高TG的各血脂异常 亚组的胰岛素抵抗指数升高较为明显，总体脂、腹部脂肪对血脂紊乱的影响较为显著；体脂对胰岛素抵抗指数的影响部分是通过TG介导的，结论：TG升高可作为个体存在胰岛纱抵抗的指标。

Dyslipidaemia and insulin resistance in Chinese in Shanghai

Objective To investigate the impact of dyslipidaemia on insulin resistance in Chinese individuals in Shanghai. Methods 830 individuals aged over 40 years (male 300,female 530) were divided into normal and dyslipidaemia groups The latter included 7 subgroups as follows: low high density lipoprotein (L HDL) subgroup I, high triglycerides (H TG) subgroup II, high total cholesterol or high low density lipoprotein (H TC/H LDL) subgroup III, low high density lipoprotein with high triglycerides (L HDL H TG) subgroup IV, low high density lipoprotein with high total cholesterol or high low density lipoprotein (L HDL H TC/H LDL) subgroup V, high triglycerides with high total cholesterol or high low density lipoprotein(H TG H TC/H LDL) subgroup VI, low high density lipoprotein with high triglycerides and high total cholesterol or high low density lipoprotein (L HDL H TG H TC/H LDL) subgroup VII Homeostasis model assessment (HOMA) was applied to estimate the degree of insulin resistance (IR) Results (1) Adjusted with age, sex and body mass index (BMI), HOMA IR was increased in the dyslipidaemia subgroups with high triglycerides (2) Hypertriglyceridemia was more closely related to raised BMI and waist hip ratio (WHR) (3) Both body fat (BMI, WHR) and triglycerides were independent risk factors accounting for HOMA IR Conclusion Hypertriglycerides could be regarded as an independent risk factor for insulin resistance