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人工肝支持系统治疗重型肝炎的疗效评价
引用本文:江元森,陈幼明,姚集鲁.人工肝支持系统治疗重型肝炎的疗效评价[J].中华内科杂志,2000,39(2):115-117.
作者姓名:江元森  陈幼明  姚集鲁
作者单位:江元森(510630 广州,中山医科大学附属第三医院传染病科)      陈幼明(510630 广州,中山医科大学附属第三医院传染病科)      姚集鲁(510630 广州,中山医科大学附属第三医院传染病科)      李学俊(510630 广州,中山医科大学附属第三医院传染病科)      曾彩虹(510630 广州,中山医科大学附属第三医院传染病科)      邓友(510630 广州,中山医科大学附属第三医院传染病科)      邓练贤(510630 广州,中山医科大学附属第三医院传染病科)      陆玮伦(510630 广州,中山医科大学附属第三医院传染病科)

基金项目:广东省自然科学基金!0 0 95,1998
摘    要:目的 探讨应用人工肝支持系统(ALSS)治疗重型肝炎肝衰竭合并肝性脑病,研究其机制及评价疗效。方法 设治疗组和对照组,治疗组51例重型肝炎(重肝)患者,急性、亚急性重肝17例,慢性重肝30例,酒精性重肝2例,钩体病黄疸型重肝1例,肝豆状核病肝衰竭1例。在综合护肝治疗基础上同时给予ALSS治疗。对照组39例重肝患者,急性、亚急性重肝8例、急性重肝31例,仅给予基础上同时给予ALSS治疗。对照组39例

关 键 词:肝功能衰竭  人工肝  支持系统  肝性脑病
修稿时间:1999-06-28

Evaluation of the therapeutic effect of artificial liver support system on severe viral hepatitis
JIANG Yuansen,CHEN Youming,YAO Jilu,et al The rd Affiliated Hospital,Sun Yat Sen University of Medical Sciences Guangzhou ,China.Evaluation of the therapeutic effect of artificial liver support system on severe viral hepatitis[J].Chinese Journal of Internal Medicine,2000,39(2):115-117.
Authors:JIANG Yuansen  CHEN Youming  YAO Jilu  The rd Affiliated Hospital  Sun Yat Sen University of Medical Sciences Guangzhou  China
Institution:JIANG Yuansen,CHEN Youming,YAO Jilu,et al The 3rd Affiliated Hospital,Sun Yat Sen University of Medical Sciences Guangzhou 510630,China
Abstract:Objective To investigate the therapeutic effect of artificial liver support system (ALSS) on severe viral hepatitis with liver function failure and hepatic encephalopathy and to evaluate the relationship between its mechanism and therapeutic effect. Methods The patients in the present study were allocated either into a treatment group or a control group, The treatment group consisted of 51 patients (mean age 40 5 years) with severe viral hepatitis, with 17 each suffering from acute and subacute severe viral hepatitis and 30 suffering from chronic severe viral hepatitis And two patients of alcoholism severe viral hepatitis, One patient of leptosphrosis icterohemorrhagie severe viral hepatitis One of hepatolenticular degeneration hepatic failure The patients received a combined hepatotheragy with ALSS The control group consisted of 39 patients with severe viral hepatitis, of 8 patients in the group of acute and subacute severe viral hepatitis And 31 patients in the group of chronic severe viral hepatitis The patients received a combined hepatotheragy Results The cure and improvement rate in the group of acute and subacute severe viral hepatitis is up to 70 6%, but that in the control group is 25 0% The cure and improvement rate in the group of chronic severe viral hepatitis is 43 3% and that in the control group is 6 5% There is marked difference between the groups ( P <0 01) and it is worth attempting so as to reduce the mortality of severe viral hepatitis Conclusions ALSS is an effective and safe means to treat severe viral hepatitis and it may be an useful support for liver transplantation
Keywords:Liver failure  Clinical trials  Artificial liver support system
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