SEPT9在结直肠癌早期检测中的研究进展

SEPT9是13个Septin同源基因家族之一，参与调控众多过程，包括细胞分裂、细胞极化、细胞迁移以及线粒体分裂等。研究表明在众多肿瘤中，SEPT9都发挥着作用，尤其在结直肠肿瘤研究领域，外周血SEPT9基因甲基化检测更是研究热点，其检测的敏感度和特异度相对于其他糖蛋白肿瘤标志物、粪便隐血试验和粪便免疫化学测试等更具有优势，相对于结直肠镜等侵入性检查更节约成本，同时有着更好的依从性。本文对SEPT9的功能、与结直肠癌之间的关系以及对结直肠肿瘤的筛查及诊断价值做一综述。

The research progress of SEPT9 in the early detection of colorectal cancer

SEPT9 is one of the 13 Septin homologous gene families involved in regulating numerous processes, including cell division, cell polarization, cell migration and mitochondrial division. Studies have shown that in many tumors, SEPT9 plays a role, especially in the field of colorectal cancer research, peripheral blood SEPT9 gene methylation detection is the research hotspot, the detection sensitivity and speciality rate relative to other glycoprotein tumor markers, fecal occult blood test and a fecal immunochemical test has more advantages, relative to colorectal colonoscopy invasive procedures it was more cost savings, at the same time with better compliance. This paper reviews the function of SEPT9, the relationship between SEPT9 and colorectal cancer, as well as the screening and diagnostic value of colorectal cancer.