血尿酸水平与慢性心力衰竭患者心功能状态的相关性分析

摘要　目的 研究血尿酸水平与慢性心衰患者心功能状态的相关性。方法：回顾收集2012年10月至2014年10月航空总医院心内科因慢性心力衰竭住院的患者200例，同期收集非心衰入院患者180例为对照组，收集患者基本资料及检验结果，采用logistic回归，分析高尿酸血症与慢性心力衰竭发生的相关性。并依据尿酸水平，将200例心衰患者分为尿酸正常组、轻度高尿酸血症组、显著高尿酸血症组，统计分析心衰患者中血尿酸水平与患者心功能状态的关系。结果：慢性心力衰竭组血尿酸水平明显高于非心衰组患者。高尿酸血症与慢性心力衰竭发生的OR 值为2. 244 ( P <0. 05)。慢性心力衰竭患者中，高尿酸血症者较尿酸正常者，心功能状态更差，且随着尿酸水平的升高，心功能指标进一步恶化。结论: 慢性心力衰竭患者高尿酸血症发生率更高，高尿酸血症可能是慢性心衰的危险因素。血尿酸水平越高，患者心功能状态越差。

Correlation Analysis of Serum Uric Acid Level and Cardiac Function in Patients with Chronic Heart Failure

ABSTRACT Objective: To study the correlation between serum uric acid level and cardiac function in patients with chronic heart failure. Methods : A total of 200 hospitalized patients with chronic heart failure in the Department of Cardiology of Aviation General Hospital from October 2012 to October 2014 were collected. 180 hospitalized patients without heart failure were collected during the same period. Logistic regression was used to analyze the association between hyperuricemia and chronic heart failure. According to the level of uric acid, 200 patients with heart failure were divided into normal uric acid group, mild hyperuricemia group and hyperuricemia group. Further analyze the relationship between serum uric acid levels and cardiac function in patients with heart failure. Results: Serum uric acid levels in patients with chronic heart failure were significantly higher than those in patients with non-heart failure. OR of hyperuricemia and chronic heart failure was 2. 244 (P <0.05). In patients with chronic heart failure, Those with hyperuricemia have worse cardiac function than those with normal uric acid. With the increase of uric acid levels, their cardiac function deteriorated further. Conclusion: The incidence of hyperuricemia in patients with chronic heart failure is higher. Hyperuricemia may be a risk factor of chronic heart failure. The level of serum uric acid is higher, the patient''s cardiac function is worse.