脑钠肽与急性冠状动脉综合征关系的研究

目的探讨脑钠肽（BNP）与急性冠状动脉综合征（ACS）的关系。方法将115例入院患者行冠状动脉造影后分为4组：稳定型心绞痛组（SAP）24例，不稳定型心绞痛组（UAP）35例，急性心肌梗死组（AMI）28例，冠状动脉造影无狭窄或狭窄〈25％者为对照组28例。测定其外周静脉血脑钠肽（BNP）水平和超敏C反应蛋白（hs—CRP）水平，分析各组BNP水平之间的关系，以及Gensim积分和hs—CRP水平与其相应的BNP水平的关系。结果①UAP组、AMI组血浆BNP浓度较对照组、SAP组明显升高（82．78±14．15）μg／L、（91．87±17．00）μg／L比（41．93±6．34）Dg／L、（45．52±6．65）μg／L]，且差异有统计学意义（P〈0．05）；SAP组血浆BNP浓度较对照组升高（45．52±6．65）μg/L比（41．93±6．34）μg／L]，但差异无统计学意义（P〉0．05）；AMI组血浆BNP浓度较UAP组升高（91．87±17．00）μg／L比（82．78±14．15）μg/L]，但差异无统计学意义（P〉0．05）。②血浆BNP浓度与其相应的Gensim积分呈明显正相关（r=0．331，P〈0．05）。③血浆BNP浓度与其相应的hs—CRP水平呈明显正相关（r=0．475，P〈0．05）。结论血浆BNP浓度可能作为预测急性冠脉综合征危险分层和判断预后的参考指标之一。

The research of the relationship between the plasma brain natriuretic peptide and acute coronary syndromes

Objective To explore the relationship between the plasma concentration of brain natriuretie peptide （BNP） and acute coronary syndromes （ACS）. Methods 115 patient who underwent coronary angiography were included in the study and divided into four groups according to extent of coronary artery stenosis： 24 patients with SAP, 35 patients with UAP, 28 patients with AMI and 28 control subjects. The concentration of BNP and hs-CRP in all subjects were measured.Tbe relationship between the concentration of BNP and Gensini score was analyzed.And the relationship between concentration of BNP and hs-CRP was analyzed. Results （1）The concen- tration of BNP in UAP and AMI group was significantly higher than that in control and SAP group （82.78± 14.15）μg/L, （91.87±17.00）μg/L vs （41.93±6.34）μg/L, （45.52±6.65）μg/L,P〈0.05 ], there was no statistical difference between the concentration of BNP in SAP and control group （45.52±6.65）μg/L vs （41.93±6.34）μg/L, P〉0.05 ], and there was no statistical difference among the concentration of BNP in UAP and AMI group （82.78± 14.15）p.g/L vs （91.87±17.00）μg/L, P〉0.05）. （2）The concentration of BNP was correlated with Gemini score（r= 0.331 ,P〈0.05 ）. （3）The concentration of BNP was correlated with the concentration of hs-CRP（r=0.475, P〈0.05 ）. Conclusion BNP may be the predictor of ACS and the degree of coronary artery stenosis.