冠心病患者血清Chemerin、hs-CRP水平变化及临床意义

摘要：目的：探讨冠心病（CHD）患者血清中脂肪因子Chemerin与超敏C反应蛋白（hs-CRP）的水平变化及临床意义。方法：选取于2016年12月至2018年5月期间我院心内科确诊为CHD且行冠状动脉造影术的患者143例作为研究组,选取同期进行入院进行冠脉造影检查单支轻度狭窄，冠状动脉阻塞程度＜30%的109例患者为对照组，采集受试者入院次日清晨空腹静脉血检测血清Chemerin、hs-CRP水平，并采用Gensini积分法评估患者冠状动脉病变程度。比较不同病变支数、Gensini积分CHD患者血清Chemerin、hs-CRP水平差异，并分析相关性。结果：研究组血清Chemerin、hs-CRP水平和Gensini积分均高于对照组（P均<0.05）。随着CHD患者的病变支数增加，血清Chemerin、hs-CRP水平、Gensini积分均显著增高；随着Genisini积分增高，血清Chemerin、hs-CRP水平均显著增高，组间差异均有统计学意义（P均<0.05）。经Pearson相关性分析，CHD患者血清Chemerin水平与hs-CRP水平呈正相关（r=0.702,P<0.05），血清Chemerin水平、hs-CRP水平均与Genisini积分成正相关（r=0.643、0.593，P均<0.05）。结论：血清Chemerin、hs-CRP升高可以反应CHD患者病变累积及病变程度，可以作为反映冠状动脉病变程度的有效指标。

Changes and clinical significance of serum Chemerin and hs-CRP level in patients with coronary heart disease

Abstract:Objectives:To investigate the changes and clinical significance of serum adipocyte factor Chemerin and high-sensitivity c-reactive protein(hs-CRP)in patients with coronary heart disease.Methods:143 patients with CHD who underwent coronary angiography in our hospital from December 2016 to May 2018 were selected as the study group.109 patients who underwent coronary angiography at the same time,with mild stenosis and coronary artery obstruction less than 30% were selected as the control group.Fasting venous blood was collected in the morning after admission, and serum Chemerin and hs-CRP level was measured.Gensini integration was used to assess the severity of coronary artery lesions.The serum level of Chemerin and hs-CRP in patients with CHD with different number of lesion branches and Gensini score was compared and the correlation was analyzed.Results:The serum Chemerin, hs-CRP level and Gensini score in the study group was higher than those in the control group (P<0.05).The level of serum Chemerin, hs-CRP and Gensini score was significantly increased with the increase of the number of lesion branches in patients with CHD.With the increase of Genisini score, the level of serum Chemerin and hs-CRP was significantly increased, and the differences between groups were statistically significant (P < 0.05).Pearson correlation analysis showed that serum Chemerin level was positively correlated with hs-CRP level in CHD patients (r=0.702, P < 0.05),serum Chemerin and hs-CRP level was positively correlated with Genisini score (r=0.643, 0.593, P < 0.05).Conclusions:The elevated level of serum Chemerin and hs-CRP can reflect the accumulation of lesions and the degree of lesions in CHD patients, and can be used as an effective index to reflect the degree of coronary artery lesions.