伴有高脂蛋白a血症的ACS患者采用瑞舒伐他汀钙和烟酸治疗的效果

【】目的 探讨伴有高脂蛋白a血症的急性冠脉综合征(ACS)患者应用瑞舒伐他汀钙和烟酸治疗的效果及对内皮功能的影响。方法 选取2015年6月至2016年7月在我院治疗的合并高脂蛋白a血症的ACS患者178例,随机分为观察组(n=80)和对照组(n=98),观察组给予瑞舒伐他汀钙和烟酸治疗,对照组给予瑞舒伐他汀钙治疗,观察两组患者治疗前后血脂、脂联素(APN)、内皮祖细胞(EPCs)及血流介导的内皮依赖性舒张功能(FMD)水平。结果 两组治疗后3个月总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL-C)和Lp(a)均较治疗前降低,而高密度脂蛋白(HDL-C)较治疗前升高(p＜0.05)；观察组治疗后3个月TG、LDL-C和Lp(a)明显低于对照组,而HDL-C明显高于对照组(p＜0.05)；两组治疗后3个月APN、EPCs及FMD均较治疗前升高(p＜0.05)；观察组治疗后3个月APN、EPCs及FMD分别为(210.40±40.27)mg/L、(0.050±0.002)%和(6.01±0.70),明显高于对照组,差异比较有统计学意义(p＜0.05)；两组患者无严重不良反应发生。结论 伴有高脂蛋白a血症的ACS患者应用瑞舒伐他汀钙和烟酸治疗有较好的效果,能有效降低脂蛋白(a)水平,改善血管内皮功能。

Effects of atorvastatin calcium and nicotinic acid in the treatment of ACS patients with #$NBShigh#$NBSplasma#$NBSlipoprotein#$NBS(a) and the changes of endothelial function

Objective:To investigate effects of atorvastatin calcium and nicotinic acid in the treatment of ACS patients with ShighSplasmaSlipoproteinS(a) and the changes of endothelial function. Methods:From June 2015 to July 2016, selected 178 ACS patients with high plasma lipoproteinS(a) who were treated in our hospital,randomly divided into observation group (n=80) and control group (n=98),The observation group was given the treatment of atorvastatin calcium and nicotinic acid,the control group was treated with atorvastatin calcium, observed two groups before and after treatmentblood lipids, adiponectin (APN), SendothelialSprogenitorSCellsS (EPCs) and flow-mediatedSdilationS (FMD).Results:TC, TG, LDL-C and Lp (a) in the two groups after treatment 3 months were lower than before treatment, while HDL-C was higher than before treatment (P < 0.05);The TG, LDL-C and Lp (a) in the observation group at 3 months after treatment were significantly lower than those in the control group, while HDL-C was significantly higher than that in the control group (P < 0.05);APN, EPCs and FMD in the two groups after treatment 3 months were higher than before treatment (P < 0.05);The observation group after treatment3 months APN, EPCs and FMD were (210.40 ± 40.27) mg/L, (0.050 ± 0.002)% and (6.01 ± 0.70), significantly higher than the control group, the difference was statistically significant (P < 0.05);No serious adverse reactions occurred in the two groups.Conclusion:The effect of atorvastatin calcium and nicotinic acid in the treatment of ACS patients with ShighSplasmaSlipoproteinS(a) is better, and it can effectively reduce the level of lipoprotein (a) and improve the vascular endothelial function.