176例急性乙型肝炎临床特点分析

目的探讨急性乙型肝炎的流行病学及临床特征。方法以同期的慢性乙型肝炎(急性发作型)作为对照,观察176例急性乙型肝炎的临床症状、体征、生化指标,病毒学标志及治疗结果,并调查其传播途径。结果急性乙型肝炎除有少部分(19%)发热外,其发病时症状、体征、生化指标均与慢性乙型肝炎(急性发作型)极为相似,经常规护肝治疗后,急性乙型肝炎肝功能均较慢性乙型肝炎(急性发作型)恢复快(P<0.05),其HBsAg及HBV DNA均在四个月内阴转。176例急性乙型肝炎患者,经性接触传播者为98例,占55.7%。结论成人急性乙型肝炎一般预后好,是否应抗病毒治疗有待进一步研究。杜绝不洁性交,注射乙型肝炎疫苗,是阻止目前急性乙型肝炎发病率上升的主要措施。

Analysis of the clinical characteristic of 176 patients with acute hepatitis B

Objective To investigate the clinical and epidemic characteristic of acute hepatitis B(AHB).Methods In comparison with chronic hepatitis B(acute attack type,CHB),176 patients with AHB were observed in respect to its clinical symptoms,signs,biochemical index,viral markers,curative effectiveness and epidemiology.Results With the exception of few patients(19%)with the AHB who had fever,the AHB were similar to the CHB in the clinical symptoms,signs and biochemical imdex.By comventional therapy,the liver function normalization in AHB were superior to the CHB(P<0.05).Serum HBsAg and HBV DNA in AHB lost in four months.98(55.7%) of 176 patients with AHB were infected through sexual intercourse(55.7%).Conclusion Owing to favorable prognosis the antiviral therapy for the AHB in adult was in controversy.At present,the main procedure in cutting down the incidence of AHB is by inoculating hepatitis B vaccine and avoiding exmarital sexual intercourse.