| 膜相关性鸟苷酸激酶与脑缺血 |
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| 引用本文： | 李庆节,徐运.膜相关性鸟苷酸激酶与脑缺血[J].国外医学：脑血管疾病分册,2013(9):711-716. |
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| 作者姓名： | 李庆节 徐运 |
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| 作者单位： | 南京医科大学鼓楼医院神经内科,210008 |
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| 基金项目： | 国家自然科学基金青年科学基金项目（81200897） |
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| 摘 要： | 膜相关性鸟苷酸激酶（membrane associated guanylate kinase,MAGUK）是一类突触后致密蛋白（postsynaptic density,PSD）,定位于突触后膜的突触后致密区,包括PSD-95、SAP-102、PSD-93和SAP-97.MAGUK家族成员含有多个蛋白结合位点,这些特殊的结合位点负责介导多种信号的转导.MAGUK参与中枢神经系统疾病发生和发展机制,已成为神经科学研究的热点.文章简要综述了MAGUK在缺血性脑损伤中的作用.
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| 关 键 词： | 脑缺血 鸟苷酸激酶 膜蛋白质类 受体 N-甲基-D-天冬氨酸 突触后密集区 |
Membrane-associated guanylate kinases and cerebral ischemia |
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| LI Qing-jie,XU Yun.Membrane-associated guanylate kinases and cerebral ischemia[J].Foreign Medical Sciences Cerebrovascular Diseases,2013(9):711-716. |
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| Authors: | LI Qing-jie XU Yun |
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| Institution: | (Department of Neurology, the Affiliated Drum Tower Hospital of Nanjing Medical University, Nanjing 210008, China) |
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| Abstract: | Membrane-associated guany late kinases （MAGUKs） is a class of postsynaptic density proteins （PSDs） in the postsynaptic dense of the postsynaptic membrane, including PSD-95, SAP-102, PSD-93, and SAP-97. MAGUK family members contain several protein binding sites, and these special binding sites are responsible for mediating a variety of sigaal transduction. MAGUKs participate in the occurrence and development mechanims in central nervous system diseases, and has become a topic of general interest of neuroscience. This article briefly reviews the roles of MAGUKs in ischemic brain injury. |
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| Keywords: | Brain Ischemia Guanylate Kinase Membrane Proteins Receptors N-Methyl-D-Aspartate Post-Synaptic Density |
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